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Discrimination of Active and Weakly Active Human BACE1 Inhibitors Using Self-Organizing Map and Support Vector Machine.

Combinatorial chemistry & high throughput screening
β-secretase (BACE1) is an aspartyl protease, which is considered as a novel vital target in Alzheimer`s disease therapy. We collected a data set of 294 BACE1 inhibitors, and built six classification models to discriminate active and weakly active inh...

Using Time Series Analysis to Predict Cardiac Arrest in a PICU.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
OBJECTIVES: To build and test cardiac arrest prediction models in a PICU, using time series analysis as input, and to measure changes in prediction accuracy attributable to different classes of time series data.

[Comparison Study of Left Ventricular Function Assessment by 18F-FDG PET, Gated SPECT and 2D-Echocardiography in Patients with Myocardial Infarction].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
The aim of this study is to analyze the concordance between EDV, ESV and LVEF values derived from 18F-FDG PET, GSPECT and ECHO in patients with myocardial infarction. Sixty-four patients with coronary artery disease (CAD) and myocardial infarction we...

Model Selection for PCA-Linear SVM for automated detection of NS1 molecule from Raman spectra of salivary mixture.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Of recent, detection of Non-structural Protein 1 (NS1) in saliva has become appealing, as it may lead to a noninvasive detection method for NS1-related diseases at the febrile phase, before complication developed. NS1 is found to have a molecular fin...

Quaternion-valued echo state networks.

IEEE transactions on neural networks and learning systems
Quaternion-valued echo state networks (QESNs) are introduced to cater for 3-D and 4-D processes, such as those observed in the context of renewable energy (3-D wind modeling) and human centered computing (3-D inertial body sensors). The introduction ...

[Application of simulated annealing method and neural network on optimizing soil sampling schemes based on road distribution].

Ying yong sheng tai xue bao = The journal of applied ecology
Taking the soil organic matter in eastern Zhongxiang County, Hubei Province, as a research object, thirteen sample sets from different regions were arranged surrounding the road network, the spatial configuration of which was optimized by the simulat...

Robust automatic breast cancer staging using a combination of functional genomics and image-omics.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Breast cancer is one of the leading cancers worldwide. Precision medicine is a new trend that systematically examines molecular and functional genomic information within each patient's cancer to identify the patterns that may affect treatment decisio...

Applying Automated MR-Based Diagnostic Methods to the Memory Clinic: A Prospective Study.

Journal of Alzheimer's disease : JAD
Several studies have demonstrated that fully automated pattern recognition methods applied to structural magnetic resonance imaging (MRI) aid in the diagnosis of dementia, but these conclusions are based on highly preselected samples that significant...

Existence and uniform stability analysis of fractional-order complex-valued neural networks with time delays.

IEEE transactions on neural networks and learning systems
This paper deals with the problem of existence and uniform stability analysis of fractional-order complex-valued neural networks with constant time delays. Complex-valued recurrent neural networks is an extension of real-valued recurrent neural netwo...