BACKGROUND: Echinococcosis, caused by Echinococcus parasites, includes alveolar echinococcosis (AE), the most lethal form, primarily affecting the liver with a 90% mortality rate without prompt treatment. While radical surgery combined with antiparas...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Sep 15, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic metabolic disorder with a rising global incidence. Epigenetic modifications-such as methylation, acetylation, phosphorylation, and ubiquitination-play critical ro...
Liver international : official journal of the International Association for the Study of the Liver
Sep 1, 2025
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major global cause of chronic liver disease, with the potential to progress from steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and cirrh...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a spectrum of chronic pathologic conditions strongly associated with metabolic syndrome and affects approximately 38 % of the global population. Untreated MASLD may progress to metab...
International journal of legal medicine
Sep 1, 2025
In forensic practice, the estimation of postmortem interval has been a persistent challenge. Recently, there has been an increasing utilization of metabolomics techniques combined with machine learning methods for postmortem interval estimation. When...
While machine learning has gained traction in toxicological assessments, the limited data availability requires the quantification of uncertainty of in silico predictions for reliable decision-making. This study addresses the challenge of predicting ...
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Liver international : official journal of the International Association for the Study of the Liver
Aug 1, 2025
We read with great interest the article by Zhang et al. The study demonstrates that the deep learning model based on high-frequency ultrasound images significantly outperforms the low-frequency ultrasound model, FIB-4, APRI, and shear wave elastograp...
Liver international : official journal of the International Association for the Study of the Liver
Jul 1, 2025
BACKGROUND AND AIMS: Liver biopsy is the gold standard for assessing fibrosis in cirrhotic livers, yet cirrhosis is spatially heterogeneous and continuously remodels. This study evaluates a novel phenotypic digital pathology platform for continuous f...
Liver international : official journal of the International Association for the Study of the Liver
Jul 1, 2025
BACKGROUND AND AIMS: To develop a deep learning model based on high-frequency ultrasound images to classify different stages of liver fibrosis in chronic hepatitis B patients.
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