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Longitudinal Studies

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A validated artificial intelligence-based pipeline for population-wide primary immunodeficiency screening.

The Journal of allergy and clinical immunology
BACKGROUND: Identification of patients with underlying inborn errors of immunity and inherent susceptibility to infection remains challenging. The ensuing protracted diagnostic odyssey for such patients often results in greater morbidity and suboptim...

Smart home technology to support older people's quality of life: A longitudinal pilot study.

International journal of older people nursing
AIM: This pilot study aimed to explore the impact of Smart Home technology to support older people's quality of life, particularly for those who live alone.

Identifying Blood Biomarkers for Dementia Using Machine Learning Methods in the Framingham Heart Study.

Cells
Blood biomarkers for dementia have the potential to identify preclinical disease and improve participant selection for clinical trials. Machine learning is an efficient analytical strategy to simultaneously identify multiple candidate biomarkers for ...

Assessment of the predictive potential of cognitive scores from retinal images and retinal fundus metadata via deep learning using the CLSA database.

Scientific reports
Accumulation of beta-amyloid in the brain and cognitive decline are considered hallmarks of Alzheimer's disease. Knowing from previous studies that these two factors can manifest in the retina, the aim was to investigate whether a deep learning metho...

Machine learning-aided risk prediction for metabolic syndrome based on 3 years study.

Scientific reports
Metabolic syndrome (MetS) is a group of physiological states of metabolic disorders, which may increase the risk of diabetes, cardiovascular and other diseases. Therefore, it is of great significance to predict the onset of MetS and the corresponding...

An Interpretable Machine Learning Approach to Predict Fall Risk Among Community-Dwelling Older Adults: a Three-Year Longitudinal Study.

Journal of general internal medicine
BACKGROUND: Adverse health effects resulting from falls are a major public health concern. Although studies have identified risk factors for falls, none have examined long-term prediction of fall risk. Furthermore, recent evidence suggests that there...

Interpretable machine learning for high-dimensional trajectories of aging health.

PLoS computational biology
We have built a computational model for individual aging trajectories of health and survival, which contains physical, functional, and biological variables, and is conditioned on demographic, lifestyle, and medical background information. We combine ...

A Framework for Using Real-World Data and Health Outcomes Modeling to Evaluate Machine Learning-Based Risk Prediction Models.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
OBJECTIVES: We propose a framework of health outcomes modeling with dynamic decision making and real-world data (RWD) to evaluate the potential utility of novel risk prediction models in clinical practice. Lung transplant (LTx) referral decisions in ...

A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure.

Nature communications
Heterogeneity of brain diseases is a challenge for precision diagnosis/prognosis. We describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial Network), a semi-supervised deep-clustering method, which examines neuroanatomical...

Network analysis of trauma in patients with early-stage psychosis.

Scientific reports
Childhood trauma (ChT) is a risk factor for psychosis. Negative lifestyle factors such as rumination, negative schemas, and poor diet and exercise are common in psychosis. The present study aimed to perform a network analysis of interactions between ...