Biological age (BA) and frailty represent two distinct health measures that offer valuable insights into the aging process. Comparing and analyzing blood-based biomarkers from the machine learning (ML) predictors of BA and frailty helps deepen our un...
International journal of molecular sciences
Apr 18, 2025
Hepatocellular carcinoma (HCC) is a major complication of tyrosinemia type 1 (HT-1), an inborn error of metabolism affecting tyrosine catabolism. The risk of HCC is higher in late diagnoses despite treatment. Alpha-fetoprotein (AFP) is widely used to...
BACKGROUND: Aging has become a global trend, and depression, as an accompanying issue, poses a significant threat to the health of middle-aged and older adults. Existing studies primarily rely on statistical methods such as logistic regression for sm...
BACKGROUND: The American Heart Association recently introduced the concept of cardiovascular-kidney-metabolic (CKM) syndrome, highlighting the increasing importance of the complex interplay between metabolic, renal, and cardiovascular diseases (CVD)....
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Apr 13, 2025
It is unclear if lithium and quetiapine have neuroprotective effects, especially in early stages of bipolar and schizoaffective disorders. Here, an age-related multivariate brain structural measure (i.e., brain-PAD) at baseline and changes in respons...
BACKGROUND: Major depressive disorder (MDD) presents significant public health challenges due to its increasing prevalence and complex risk factors. This study systematically analyzed data from 2019 to 2023 to explore trends in MDD incidence, symptom...
Radiological expertise develops through extensive experience in specific imaging modalities. While previous research has focused on long-term learning and neural mechanisms of expertise, the effects of short-term radiological training on resting-stat...
BACKGROUND: Suicide is the second leading cause of death among early adolescents, yet the first onset of suicide attempts during this critical developmental period remains poorly understood. This study aimed to identify key characteristics associated...
BACKGROUND: While the Cardiometabolic Index (CMI) serves as a novel marker for assessing adipose tissue distribution and metabolic function, its prognostic utility for cardiovascular disease (CVD) events remains incompletely understood. This investig...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Mar 27, 2025
Longitudinal liver tumor segmentation plays a fundamental role in studying and monitoring the progression of associated diseases. The correlation and differences between longitudinal data can further improve segmentation performance, which are inevit...
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