AIMC Topic: Machine Learning

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Logistic regression paradigm for training a single-hidden layer feedforward neural network. Application to gene expression datasets for cancer research.

Journal of biomedical informatics
OBJECTIVE: The speed of the diagnosis process is vital in pursuing the trial of curing cancer. During the last decade, precision medicine evolved by detecting different types of cancer through microarrays (MA) of deoxyribonucleic acid (DNA) processed...

Robust Prediction of Single and Multiple Point Protein Mutations Stability Changes.

Biomolecules
Accurate prediction of protein stability changes resulting from amino acid substitutions is of utmost importance in medicine to better understand which mutations are deleterious, leading to diseases, and which are neutral. Since conducting wet lab ex...

Applications of machine learning in decision analysis for dose management for dofetilide.

PloS one
BACKGROUND: Initiation of the antiarrhythmic medication dofetilide requires an FDA-mandated 3 days of telemetry monitoring due to heightened risk of toxicity within this time period. Although a recommended dose management algorithm for dofetilide exi...

Multicenter validation of a machine-learning algorithm for 48-h all-cause mortality prediction.

Health informatics journal
In order to evaluate mortality predictions based on boosted trees, this retrospective study uses electronic medical record data from three academic health centers for inpatients 18 years or older with at least one observation of each vital sign. Pred...

Global collaboration through local interaction in competitive learning.

Neural networks : the official journal of the International Neural Network Society
Feature maps, that preserve the global topology of arbitrary datasets, can be formed by self-organizing competing agents. So far, it has been presumed that global interaction of agents is necessary for this process. We establish that this is not the ...

Breast tumor classification through learning from noisy labeled ultrasound images.

Medical physics
PURPOSE: To train deep learning models to differentiate benign and malignant breast tumors in ultrasound images, we need to collect many training samples with clear labels. In general, biopsy results can be used as benign/malignant labels. However, m...

Using transfer learning from prior reference knowledge to improve the clustering of single-cell RNA-Seq data.

Scientific reports
In many research areas scientists are interested in clustering objects within small datasets while making use of prior knowledge from large reference datasets. We propose a method to apply the machine learning concept of transfer learning to unsuperv...

Rule-based and machine learning algorithms identify patients with systemic sclerosis accurately in the electronic health record.

Arthritis research & therapy
BACKGROUND: Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated methods are needed. We devel...