Journal of chemical information and modeling
Mar 4, 2019
Predicting the activity of new chemical compounds over pathogenic microorganisms with different metabolic reaction networks (MRN ) is an important goal due to the different susceptibility to antibiotics. The ChEMBL database contains >160 000 outcomes...
The early detection of cognitive impairment is a key issue among the elderly. Although neuroimaging, genetic, and cerebrospinal measurements show promising results, high costs and invasiveness hinder their widespread use. Predicting cognitive impairm...
Hearing loss (HL) is the most common neurodegenerative disease worldwide. Despite its prevalence, clinical testing does not yield a cell or molecular based identification of the underlying etiology of hearing loss making development of pharmacologica...
Accurate detection of somatic mutations is still a challenge in cancer analysis. Here we present NeuSomatic, the first convolutional neural network approach for somatic mutation detection, which significantly outperforms previous methods on different...
BACKGROUND: Deep learning has made tremendous successes in numerous artificial intelligence applications and is unsurprisingly penetrating into various biomedical domains. High-throughput omics data in the form of molecular profile matrices, such as ...
Computational intelligence and neuroscience
Mar 3, 2019
We propose a novel end-to-end approach, namely, the semantic-containing double-level embedding Bi-LSTM model (SCDE-Bi-LSTM), to solve the three key problems of Q&A matching in the Chinese medical field. In the similarity calculation of the Q&A core m...
Journal of the American College of Radiology : JACR
Mar 2, 2019
OBJECTIVE: Radiology is a finite health care resource in high demand at most health centers. However, anticipating fluctuations in demand is a challenge because of the inherent uncertainty in disease prognosis. The aim of this study was to explore th...
BACKGROUND AND PURPOSE: The unanticipated detection by magnetic resonance imaging (MRI) in the brain of asymptomatic subjects of white matter lesions suggestive of multiple sclerosis (MS) has been named radiologically isolated syndrome (RIS). As the ...
Biological psychiatry. Cognitive neuroscience and neuroimaging
Mar 1, 2019
The incidence of alcohol use disorder (AUD) in human immunodeficiency virus (HIV) infection is twice that of the rest of the population. This study documents complex radiologically identified, neuroanatomical effects of AUD+HIV comorbidity by identif...
Machine-learning approaches (MLAs) for DNA barcoding outperform distance- and tree-based methods on identification accuracy and cost-effectiveness to arrive at species-level identification of wood. DNA barcoding is a promising tool to combat illegal ...
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