Perfluorooctanoic acid (PFOA), a widely used industrial chemical, poses significant environmental and biological toxicity, particularly affecting reproductive health. This study aimed to integrate network toxicology, machine learning, and molecular d...
Healthcare remains a critical focus due to its direct impact on human well-being. Diabetes, currently the fastest-growing chronic disease globally, poses severe health risks, including cardiovascular complications and kidney failure. Simultaneously, ...
INTRODUCTION: Hip fractures, particularly among the elderly, impose a significant public health burden due to increased morbidity and mortality. Femoral neck fractures, commonly resulting from low-energy falls, can lead to severe complications such a...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 1, 2025
Most lung cancer (LC) patients are diagnosed at advanced stages due to the lack of effective screening tools. This multicenter study analyzes 1043 saliva samples (334 LC cases and 709 non-LC cases) using a novel high-throughput platform for metabolic...
Cardiovascular diseases comprise a diverse array of disorders impacting the cardiac structure and vascular system and rank among the predominant factors contributing to mortality on a global scale. Every day, a significant number of individuals die f...
MOTIVATION: Accurately predicting drug-target interactions (DTIs) is critical for accelerating drug discovery, repositioning, and development. Traditional experimental methods are often expensive and time-consuming, emphasizing the need for efficient...
Blood pressure is a critical risk factor for cardiovascular diseases (CVDs), yet most adults do not monitor it frequently enough to prevent serious complications. This is in part because the traditional cuff-based method is inconvenient, uncomfortabl...
CPT: pharmacometrics & systems pharmacology
Jun 1, 2025
Selective serotonin reuptake inhibitors (SSRIs) are widely used in depression treatment. However, the relationship between treatment efficacy and plasma concentrations remains unclear. We assessed whether the anti-depressive response can be predicted...
Food research international (Ottawa, Ont.)
Jun 1, 2025
The rapid identification of coffee species and origin is critical for ensuring quality control and authenticity in the coffee industry. This study explores the use of an affordable multi-channel spectral sensor, AS7265X (410-940 nm), combined with ma...
Food research international (Ottawa, Ont.)
Jun 1, 2025
Per- and polyfluoroalkyl substances (PFAS) contamination in aquatic and terrestrial organisms poses significant environmental and health risks. This study quantified 15 PFAS compounds across various tissues (liver, kidney, gill, muscle, skin, lung, b...
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