Physical chemistry chemical physics : PCCP
Jan 14, 2026
Recent advances in machine learning and self-supervised deep language modeling have made it possible to accurately predict protein structural properties. Most existing models and pretraining methods leverage evolutionary information in multiple seque...
BACKGROUND: The referral process between healthcare services can be complex, especially in psychiatry, leading to significant delays and 'hidden waiting lists'. Digital approaches may be helpful. The CHRONOSIG (CHRONOlogical SIGnature) project aims t...
Tree bark represents a large global carbon stock, comprising 2-20 % of woody biomass, and plays a distinct role in carbon and nutrient cycling. It is poorly understood how different abiotic and biotic drivers contribute to bark decomposition globally...
BACKGROUND: Metastatic cancer remains one of the leading causes of cancer-related mortality worldwide. Yet, the prediction of survivability in this population remains limited by heterogeneous clinical presentations and high-dimensional molecular feat...
BACKGROUND: Adult-type diffuse glioma (ADG) is the most common primary malignant tumor of the central nervous system. Its highly invasive nature, marked heterogeneity, and resistance to therapy contribute to a high risk of recurrence and poor prognos...
Acute myocardial infarction (AMI) remains a leading cause of global cardiovascular morbidity and mortality. Limitations in current diagnostic methods hinder early detection and intervention, creating an urgent need for novel early diagnostic biomarke...
Aquatic organisms exhibit remarkable diversity in swimming strategies, even within shared modes such as body-caudal fin (BCF) propulsion. Here, we investigate the biomechanical underpinnings of BCF swimming by mapping performance trade-offs across a ...
Chemical communications (Cambridge, England)
Jan 13, 2026
The interaction of proteins with diverse molecular partners, including other proteins, nucleic acids, and carbohydrates, is essential for performing various functions, from signal transduction and gene regulation to immune recognition and cellular tr...
Journal of neurointerventional surgery
Jan 13, 2026
BACKGROUND: Automated machine learning (ML)-based large vessel occlusion (LVO) detection algorithms have been shown to improve in-hospital workflow metrics including door-to-groin time (DTG). The degree to which care team engagement and interaction a...
Epigenetic regulation orchestrates mammalian transcription, but functional links between them remain elusive. To tackle this problem, we use epigenomic and transcriptomic data from 13 ENCODE cell types to train machine learning models to predict gene...
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