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An end-to-end interpretable machine-learning-based framework for early-stage diagnosis of gallbladder cancer using multi-modality medical data.

BMC cancer
BACKGROUND: The accurate early-stage diagnosis of gallbladder cancer (GBC) is regarded as one of the major challenges in the field of oncology. However, few studies have focused on the comprehensive classification of GBC based on multiple modalities....

Multi-tissue Methylation Analysis of Alzheimer's Disease: Insights into Pathways, Modules, and Key Genes.

Journal of molecular neuroscience : MN
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...

Image quality and radiation dose of reduced-dose abdominopelvic computed tomography (CT) with silver filter and deep learning reconstruction.

Scientific reports
To assess the image quality and radiation dose between reduced-dose CT with deep learning reconstruction (DLR) using SilverBeam filter and standard dose with iterative reconstruction (IR) in abdominopelvic CT. In total, 182 patients (mean age ± stand...

Analysis of the mechanism of physical activity enhancing well-being among college students using artificial neural network.

Scientific reports
This study explores the impact mechanism of college students' sports behavior on their well-being by constructing an Artificial Neural Network (ANN) model. The study employs an ANN architecture that combines a Long Short-Term Memory (LSTM) network an...

Machine learning to evaluate the effects of non-clinical social determinant features in predicting colorectal Cancer mortality in a medically underserved Appalachian population.

Scientific reports
Colorectal cancer (CRC) is the 2nd leading cause of cancer death in the United States (US). Rural Appalachia suffers the highest CRC incidence and mortality rates. There are several non-clinical health-related social determinant factors (SDOH) associ...

Voice fatigue subtyping through individual modeling of vocal demand reponses.

Scientific reports
Recognizing individual variability is essential for developing targeted, personalized medical interventions. Vocal fatigue is a prevalent symptom and complaint among occupational voice users, but its identification has yielded mixed results. Vocal fa...

Artificial intelligence-based diabetes risk prediction from longitudinal DXA bone measurements.

Scientific reports
Diabetes mellitus (DM) is a serious global health concern that poses a significant threat to human life. Beyond its direct impact, diabetes substantially increases the risk of developing severe complications such as hypertension, cardiovascular disea...

Developing an explainable machine learning and fog computing-based visual rating scale for the prediction of dementia progression.

Scientific reports
Recently, dementia research has primarily concentrated on using Magnetic Resonance Imaging (MRI) to develop learning models in processing and analyzing brain data. However, these models often cannot provide early detection of affected brain regions. ...

Multi-scale machine learning model predicts muscle and functional disease progression.

Scientific reports
Facioscapulohumeral muscular dystrophy (FSHD) is a genetic neuromuscular disorder characterized by progressive muscle degeneration with substantial variability in severity and progression patterns. FSHD is a highly heterogeneous disease; however, cur...

Automatic segmentation of liver structures in multi-phase MRI using variants of nnU-Net and Swin UNETR.

Scientific reports
Accurate segmentation of the liver parenchyma, portal veins, hepatic veins, and lesions from MRI is important for hepatic disease monitoring and treatment. Multi-phase contrast enhanced imaging is superior in distinguishing hepatic structures compare...