AIMC Topic: Membrane Proteins
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Computational drug development for membrane protein targets.
Nature biotechnology
Feb 15, 2024
The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine ...
Integrated Bioinformatics and Validation Reveal and Its Related Molecules as Potential Identifying Genes in Liver Cirrhosis.
Biomolecules
Dec 21, 2023
Liver cirrhosis remains a significant global public health concern, with liver transplantation standing as the foremost effective treatment currently available. Therefore, investigating the pathogenesis of liver cirrhosis and developing novel therapi...
Prediction of interactions between cell surface proteins by machine learning.
Proteins
Dec 5, 2023
Cells detect changes in their external environments or communicate with each other through proteins on their surfaces. These cell surface proteins form a complicated network of interactions in order to fulfill their functions. The interactions betwee...
Identifying Explainable Machine Learning Models and a Novel SFRP2 Fibroblast Signature as Predictors for Precision Medicine in Ovarian Cancer.
International journal of molecular sciences
Nov 29, 2023
Ovarian cancer (OC) is a type of malignant tumor with a consistently high mortality rate. The diagnosis of early-stage OC and identification of functional subsets in the tumor microenvironment are essential to the development of patient management st...
MPA-Pred: A machine learning approach for predicting the binding affinity of membrane protein-protein complexes.
Proteins
Nov 10, 2023
Membrane protein-protein interactions are essential for several functions including cell signaling, ion transport, and enzymatic activity. These interactions are mainly dictated by their binding affinities. Although several methods are available for ...
PortPred: Exploiting deep learning embeddings of amino acid sequences for the identification of transporter proteins and their substrates.
Journal of cellular biochemistry
Oct 25, 2023
The physiology of every living cell is regulated at some level by transporter proteins which constitute a relevant portion of membrane-bound proteins and are involved in the movement of ions, small and macromolecules across bio-membranes. The importa...
Integrating Pre-Trained protein language model and multiple window scanning deep learning networks for accurate identification of secondary active transporters in membrane proteins.
Methods (San Diego, Calif.)
Oct 21, 2023
Secondary active transporters play pivotal roles in regulating ion and molecule transport across cell membranes, with implications in diseases like cancer. However, studying transporters via biochemical experiments poses challenges. We propose an eff...
Exploring the World of Membrane Proteins: Techniques and Methods for Understanding Structure, Function, and Dynamics.
Molecules (Basel, Switzerland)
Oct 19, 2023
In eukaryotic cells, membrane proteins play a crucial role. They fall into three categories: intrinsic proteins, extrinsic proteins, and proteins that are essential to the human genome (30% of which is devoted to encoding them). Hydrophobic interacti...
Disclosing the locale of transmembrane proteins within cellular alcove by machine learning approach: systematic review and meta analysis.
Journal of biomolecular structure & dynamics
Sep 28, 2023
Protein subcellular localization is a promising research question in Proteomics and associated fields, including Biological Sciences, Biomedical Engineering, Computational Biology, Bioinformatics, Proteomics, Artificial Intelligence, and Biophysics. ...
Efficient Generation of Paired Single-Cell Multiomics Profiles by Deep Learning.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Apr 28, 2023
Recent advances in single-cell sequencing technology have made it possible to measure multiple paired omics simultaneously in a single cell such as cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) and single-nucleus chromatin...
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