AIMC Topic: Metabolic Networks and Pathways

Clear Filters Showing 31 to 40 of 119 articles

DeepRF: A deep learning method for predicting metabolic pathways in organisms based on annotated genomes.

Computers in biology and medicine Jun 20, 2022
The rapid increase of metabolomics has led to an increasing focus on metabolic pathway modeling and reconstruction. In particular, reconstructing an organism's metabolic network based on its genome sequence is a key challenge in systems biology. The ...
Neural Networks, Computer Databases, Factual Deep Learning Metabolic Networks and Pathways Genome
View on PubMed DOI

Machine Learning Study of Metabolic Networks ChEMBL Data of Antibacterial Compounds.

Molecular pharmaceutics Jun 7, 2022
Antibacterial drugs (AD) change the metabolic status of bacteria, contributing to bacterial death. However, antibiotic resistance and the emergence of multidrug-resistant bacteria increase interest in understanding metabolic network (MN) mutations an...
Algorithms Anti-Bacterial Agents Databases, Factual Metabolic Networks and Pathways Machine Learning
View on PubMed DOI

Establishment of a Combined Diagnostic Model of Abdominal Aortic Aneurysm with Random Forest and Artificial Neural Network.

BioMed research international Mar 7, 2022
OBJECTIVES: Abdominal aortic aneurysm (AAA), a disease with high mortality, is limited by the current diagnostic methods in the early screening. This study aimed to screen novel and significant biomarkers and construct a diagnostic model for AAA by u...
Neural Networks, Computer Diagnosis, Computer-Assisted Databases, Genetic Aortic Aneurysm, Abdominal Humans Metabolic Networks and Pathways Gene Ontology
View on PubMed DOI

Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology.

Journal of the American Society of Nephrology : JASN Jan 11, 2022
BACKGROUND: Untargeted plasma metabolomic profiling combined with machine learning (ML) may lead to discovery of metabolic profiles that inform our understanding of pediatric CKD causes. We sought to identify metabolomic signatures in pediatric CKD b...
Metabolic Networks and Pathways Glomerulosclerosis, Focal Segmental Support Vector Machine Metabolomics Metabolome Infant Adolescent Cohort Studies Child, Preschool Machine Learning Child Humans Kidney Prospective Studies Logistic Models Female Renal Insufficiency, Chronic Male
View on PubMed DOI

Precise Prediction of Promoter Strength Based on a De Novo Synthetic Promoter Library Coupled with Machine Learning.

ACS synthetic biology Dec 19, 2021
Promoters are one of the most critical regulatory elements controlling metabolic pathways. However, the fast and accurate prediction of promoter strength remains challenging, leading to time- and labor-consuming promoter construction and characteriza...
Artificial Intelligence Machine Learning Metabolic Networks and Pathways Promoter Regions, Genetic Gene Library
View on PubMed DOI

Genetic dissection of complex traits using hierarchical biological knowledge.

PLoS computational biology Sep 17, 2021
Despite the growing constellation of genetic loci linked to common traits, these loci have yet to account for most heritable variation, and most act through poorly understood mechanisms. Recent machine learning (ML) systems have used hierarchical bio...
Copper Mutation Glucose Glycine Knowledge Bases Saccharomyces cerevisiae Gene Ontology Hydroxyurea Benomyl Neural Networks, Computer Chromosome Mapping Computational Biology Nucleotidyltransferases Phenotype Machine Learning Multifactorial Inheritance Systems Biology Genome-Wide Association Study Models, Genetic Polymorphism, Single Nucleotide Metabolic Networks and Pathways
View on PubMed DOI

Polycystic ovary syndrome: clinical and laboratory variables related to new phenotypes using machine-learning models.

Journal of endocrinological investigation Sep 15, 2021
PURPOSE: Polycystic Ovary Syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age. Machine learning (ML) is the area of artificial intelligence with a focus on predictive computing algorithms. We aimed to define the most rele...
Disease Hotspot Polycystic Ovary Syndrome Preventive Health Services Biological Variation, Population Machine Learning Algorithms Precision Medicine Female Adult Insulin Resistance Body Mass Index Humans Metabolic Networks and Pathways Artificial Intelligence
View on PubMed DOI

Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome.

Scientific reports Sep 1, 2021
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may ...
Metabolome Metabolic Networks and Pathways Infant Bacteria Gastrointestinal Microbiome Prospective Studies Female Infant, Newborn Cesarean Section Drug Delivery Systems Humans Cross-Sectional Studies Machine Learning Male Anti-Bacterial Agents
View on PubMed DOI

Applications of artificial intelligence to enzyme and pathway design for metabolic engineering.

Current opinion in biotechnology Aug 3, 2021
Metabolic engineering for developing industrial strains capable of overproducing bioproducts requires good understanding of cellular metabolism, including metabolic reactions and enzymes. However, metabolic pathways and enzymes involved are still unk...
Protein Engineering Metabolic Engineering Artificial Intelligence Metabolic Networks and Pathways Biosynthetic Pathways
View on PubMed DOI

Identification of kinase inhibitors that rule out the CYP27B1-mediated activation of vitamin D: an integrated machine learning and structure-based drug designing approach.

Molecular diversity Jul 16, 2021
CYP27B1, a cytochrome P450-containing hydroxylase enzyme, converts vitamin D precursor calcidiol (25-hydroxycholecalciferol) to its active form calcitriol (1α,25(OH)D). Tyrosine kinase inhibitor such as imatinib is reported to interfere with the acti...
Enzyme Inhibitors Drug Design Binding Sites Protein Binding Phosphotransferases Small Molecule Libraries Models, Molecular Algorithms Support Vector Machine Vitamin D Databases, Pharmaceutical Molecular Dynamics Simulation Humans Reproducibility of Results 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Amino Acid Sequence Neural Networks, Computer Animals Structure-Activity Relationship Machine Learning Molecular Docking Simulation Metabolic Networks and Pathways
View on PubMed DOI
Popular Topics
Recent Journals