AIMC Topic: Mice, Transgenic

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From Genes to Metabolites: HSP90B1's Role in Alzheimer's Disease and Potential for Therapeutic Intervention.

Neuromolecular medicine Jan 6, 2025
Alzheimer's disease (AD) is a prototypical neurodegenerative disorder, predominantly affecting individuals in the presenile and elderly populations, with an etiology that remains elusive. This investigation aimed to elucidate the alterations in anoik...
Animals Male Mice Disease Models, Animal Machine Learning Biomarkers Female Aged Alzheimer Disease Hippocampus Gene Expression Regulation Mice, Transgenic HSP90 Heat-Shock Proteins Mice, Inbred C57BL Cell Survival MicroRNAs Amyloid beta-Peptides Humans
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G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework.

The Journal of neuroscience : the official journal of the Society for Neuroscience Nov 6, 2024
Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide ...
Computational Biology Signal Transduction Supervised Machine Learning Alzheimer Disease Male Humans Deep Learning Mice, Transgenic Brain Protein Interaction Maps Female Mice Animals GTP-Binding Proteins Amyloid beta-Protein Precursor
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Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models.

Cell reports Oct 19, 2024
Computer-vision and machine-learning (ML) approaches are being developed to provide scalable, unbiased, and sensitive methods to assess mouse behavior. Here, we used the ML-based variational animal motion embedding (VAME) segmentation platform to ass...
Humans Machine Learning Female Animals Mice, Inbred C57BL Alzheimer Disease Behavior, Animal Mice, Transgenic Amyloid beta-Protein Precursor Male Mice Treatment Outcome Disease Models, Animal
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AnNoBrainer, An Automated Annotation of Mouse Brain Images using Deep Learning.

Neuroinformatics Aug 7, 2024
Annotation of multiple regions of interest across the whole mouse brain is an indispensable process for quantitative evaluation of a multitude of study endpoints in neuroscience digital pathology. Prior experience and domain expert knowledge are the ...
Deep Learning Image Processing, Computer-Assisted Mice Mice, Transgenic Software Brain Reproducibility of Results Animals
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Inferring Parameters of Pyramidal Neuron Excitability in Mouse Models of Alzheimer's Disease Using Biophysical Modeling and Deep Learning.

Bulletin of mathematical biology Mar 25, 2024
Alzheimer's disease (AD) is believed to occur when abnormal amounts of the proteins amyloid beta and tau aggregate in the brain, resulting in a progressive loss of neuronal function. Hippocampal neurons in transgenic mice with amyloidopathy or tauopa...
Potassium Alzheimer Disease Mice Mice, Transgenic Pyramidal Cells Animals Mathematical Concepts Disease Models, Animal Deep Learning Amyloid beta-Peptides Tauopathies Models, Biological
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Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Mar 20, 2024
Parkinson's disease (PD) is a complex neurodegenerative disorder with an unclear etiology. Despite significant research efforts, developing disease-modifying treatments for PD remains a major unmet medical need. Notably, drug repositioning is becomin...
Caenorhabditis elegans Alkynes Benzoxazines Nevirapine Parkinson Disease Drug Repositioning Mice alpha-Synuclein Disease Models, Animal Humans Mice, Transgenic Mice, Inbred C57BL Artificial Intelligence Cyclopropanes Animals
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Distribution Patterns of Subgroups of Inhibitory Neurons Divided by Calbindin 1.

Molecular neurobiology Aug 7, 2023
The inhibitory neurons in the brain play an essential role in neural network firing patterns by releasing γ-aminobutyric acid (GABA) as the neurotransmitter. In the mouse brain, based on the protein molecular markers, inhibitory neurons are usually t...
Neural Networks, Computer Brain Animals Mice Neurons Mice, Transgenic Parvalbumins Calbindin 1
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Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Apr 26, 2022
Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer's Disease (AD) with sex differences. This study aimed to determine the effect of ...
Disease Models, Animal Alzheimer Disease Mice, Transgenic Inositol Weight Loss Insulin Humans Mice Female Insulin Resistance Animals Male
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MesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning.

Nature communications Oct 13, 2021
Understanding the basis of brain function requires knowledge of cortical operations over wide spatial scales and the quantitative analysis of brain activity in well-defined brain regions. Matching an anatomical atlas to brain functional data requires...
Mice, Transgenic Atlases as Topic Cerebral Cortex Optical Imaging Machine Learning Nerve Net Stereotaxic Techniques Algorithms Male Image Processing, Computer-Assisted Mice Brain Mapping Animals
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Automated Detection and Diameter Estimation for Mouse Mesenteric Artery Using Semantic Segmentation.

Journal of vascular research Jun 28, 2021
BACKGROUND: Pressurized myography is useful for the assessment of small artery structures and function. However, this procedure requires technical expertise for sample preparation and effort to choose an appropriate sized artery. In this study, we de...
Neural Networks, Computer Mesenteric Arteries Machine Learning Mice, Inbred C57BL Automation Animals Mesenteric Veins Predictive Value of Tests Phenotype Arterial Pressure Male Microscopy Female Mice, Transgenic Mice Image Interpretation, Computer-Assisted Genotype Myography
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