Biohybrid actuators using muscle rings have been limited to twitching movements and are unsuitable for sustained contractile force applications. In this study, we developed muscle rings capable of generating high contractile forces under tetanus stim...
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive pulmonary disease characterized by alveolar structural destruction and fibrosis. In recent years, efferocytosis has been recognized as playing a crucial role in the occurrence a...
Animal behavior is crucial for understanding both normal brain function and dysfunction. To facilitate behavior analysis of mice within their home environments, we developed DeepEthoProfile, an open-source software powered by a deep convolutional neu...
Advances in in vivo Ca imaging using miniature microscopes have enabled researchers to study single-neuron activity in freely moving animals. Tools such as Minian and CalmAn have been developed to convert Ca visual signals to numerical data, collecti...
Clinica chimica acta; international journal of clinical chemistry
Jul 14, 2025
BACKGROUND: Necroptosis is inflammatorily sparked and closely associated with sepsis, but the crosstalk between necroptosis and inflammation in sepsis has rarely been studied in depth. This study is designed to reveal the role of necroptosis in the p...
Innovative identification technologies for hematopoietic stem cells (HSCs) have expanded the scope of stem cell biology. Clinically, the functional quality of HSCs critically influences the safety and therapeutic efficacy of stem cell therapies. Howe...
ETHNOPHARMACOLOGICAL RELEVANCE: Erzhi Pill (EZP), a traditional Chinese medicine used for various cancers, exhibits antitumor potential, though its role and mechanisms in Triple-Negative Breast Cancer (TNBC) remain unclear.
The rise of antibiotic-resistant pathogens, particularly gram-negative bacteria, highlights the urgent need for novel therapeutics. Drug-resistant infections now contribute to approximately 5 million deaths annually, yet traditional antibiotic discov...
Lactate dehydrogenase A (LDHA) is a promising target for cancer therapy due to its crucial role in aerobic glycolysis. Despite extensive efforts, the structural diversity of LDHA inhibitors remains limited. Here, we utilized machine learning techniqu...
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