AIMC Topic: Mice

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Integrated structural proteomics and machine learning-guided mapping of a highly protective precision vaccine against mycoplasma pulmonis.

International immunopharmacology Aug 16, 2024
Mycoplasma pulmonis (M. pulmonis) is an emerging respiratory infection commonly linked to prostate cancer, and it is classified under the group of mycoplasmas. Improved management of mycoplasma infections is essential due to the frequent ineffectiven...
Bacterial Proteins Antigens, Bacterial Epitopes, B-Lymphocyte Bacterial Vaccines Molecular Docking Simulation Mice Proteomics Epitope Mapping T-Lymphocytes, Cytotoxic Mycoplasma Infections Animals Epitopes, T-Lymphocyte Humans Machine Learning
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Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models.

Journal of controlled release : official journal of the Controlled Release Society Aug 16, 2024
Nanoparticles (NPs) can be designed for targeted delivery in cancer nanomedicine, but the challenge is a low delivery efficiency (DE) to the tumor site. Understanding the impact of NPs' physicochemical properties on target tissue distribution and tum...
Tissue Distribution Drug Delivery Systems Animals Neoplasms Nanoparticles Nanomedicine Antineoplastic Agents Mice Neural Networks, Computer Machine Learning
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Integration of Animal Behavioral Assessment and Convolutional Neural Network to Study Wasabi-Alcohol Taste-Smell Interaction.

Journal of visualized experiments : JoVE Aug 16, 2024
The commercial wasabi pastes commonly used for food preparation contain a homologous compound of chemosensory isothiocyanates (ITCs) that elicit an irritating sensation upon consumption. The impact of sniffing dietary alcoholic beverages on the sensa...
Smell Mice Neural Networks, Computer Behavior, Animal Animals Ethanol Isothiocyanates Male Taste
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Machine Learning-Assisted Near-Infrared Spectral Fingerprinting for Macrophage Phenotyping.

ACS nano Aug 15, 2024
Spectral fingerprinting has emerged as a powerful tool that is adept at identifying chemical compounds and deciphering complex interactions within cells and engineered nanomaterials. Using near-infrared (NIR) fluorescence spectral fingerprinting coup...
Machine Learning Animals Spectroscopy, Near-Infrared Macrophages Phenotype RAW 264.7 Cells Mice DNA Nanotubes, Carbon
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Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data.

Journal of neuroscience methods Aug 14, 2024
BACKGROUND: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of wa...
Sleep Sleep Stages Neural Networks, Computer Electroencephalography Brain Animals Image Processing, Computer-Assisted Calcium Attention Male Mice Wakefulness Mice, Inbred C57BL
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Structured adaptive boosting trees for detection of multicellular aggregates in fluorescence intravital microscopy.

Microvascular research Aug 13, 2024
Fluorescence intravital microscopy captures large data sets of dynamic multicellular interactions within various organs such as the lungs, liver, and brain of living subjects. In medical imaging, edge detection is used to accurately identify and deli...
Cell Aggregation Image Interpretation, Computer-Assisted Blood Platelets Intravital Microscopy Animals Machine Learning Lung Algorithms Predictive Value of Tests Mice Neutrophils Reproducibility of Results Microscopy, Fluorescence Mice, Inbred C57BL
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Mechanisms of QingRe HuoXue Formula in atherosclerosis Treatment: An integrated approach using Bioinformatics, Machine Learning, and experimental validation.

International immunopharmacology Aug 12, 2024
BACKGROUND: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription of traditional Chinese medicine, has a definite effect on the cli...
Animals Male Molecular Docking Simulation Gene Expression Profiling Humans Machine Learning Mice, Inbred C57BL Drugs, Chinese Herbal Atherosclerosis Plaque, Atherosclerotic Mice Computational Biology Disease Models, Animal Collagen Type I Collagen Type I, alpha 1 Chain
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Accurate neuron segmentation method for one-photon calcium imaging videos combining convolutional neural networks and clustering.

Communications biology Aug 9, 2024
One-photon fluorescent calcium imaging helps understand brain functions by recording large-scale neural activities in freely moving animals. Automatic, fast, and accurate active neuron segmentation algorithms are essential to extract and interpret in...
Image Processing, Computer-Assisted Mice Cluster Analysis Neurons Calcium Software Algorithms Brain Animals Neural Networks, Computer
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RS-Net: An end-to-end deep learning framework for rodent skull stripping in multi-center brain MRI.

NeuroImage Aug 8, 2024
Skull stripping is a crucial preprocessing step in magnetic resonance imaging (MRI), where experts manually create brain masks. This labor-intensive process heavily relies on the annotator's expertise, as automation faces challenges such as low tissu...
Brain Animals Deep Learning Rats Image Processing, Computer-Assisted Skull Magnetic Resonance Imaging Mice
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AnNoBrainer, An Automated Annotation of Mouse Brain Images using Deep Learning.

Neuroinformatics Aug 7, 2024
Annotation of multiple regions of interest across the whole mouse brain is an indispensable process for quantitative evaluation of a multitude of study endpoints in neuroscience digital pathology. Prior experience and domain expert knowledge are the ...
Software Deep Learning Image Processing, Computer-Assisted Mice Mice, Transgenic Brain Reproducibility of Results Animals
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