AIMC Topic: Microbiota

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Transition from sulfur autotrophic to mixotrophic denitrification: Performance with different carbon sources, microbial community and artificial neural network modeling.

Chemosphere
To address the limitations inherent in both sulfur autotrophic denitrification (SAD) and heterotrophic denitrification (HD) processes, this study introduces a novel approach. Three carbon sources (glucose, methanol, and sodium acetate) were fed into ...

Microbe-drug association prediction model based on graph convolution and attention networks.

Scientific reports
The human microbiome plays a key role in drug development and precision medicine, but understanding its complex interactions with drugs remains a challenge. Identifying microbe-drug associations not only enhances our understanding of their mechanisms...

Bioinformatics challenges for profiling the microbiome in cancer: pitfalls and opportunities.

Trends in microbiology
Increasing evidence suggests that the human microbiome plays an important role in cancer risk and treatment. Untargeted 'omics' techniques have accelerated research into microbiome-cancer interactions, supporting the discovery of novel associations a...

Integrating respiratory microbiome and host immune response through machine learning for respiratory tract infection diagnosis.

NPJ biofilms and microbiomes
At present, the diagnosis of lower respiratory tract infections (LRTIs) is difficult, and there is an urgent need for better diagnostic methods. This study enrolled 136 patients from 2020 to 2021 and collected bronchoalveolar lavage fluid (BALF) spec...

Preventing illegal seafood trade using machine-learning assisted microbiome analysis.

BMC biology
BACKGROUND: Seafood is increasingly traded worldwide, but its supply chain is particularly prone to frauds. To increase consumer confidence, prevent illegal trade, and provide independent validation for eco-labelling, accurate tools for seafood trace...

Semi-supervised meta-learning elucidates understudied molecular interactions.

Communications biology
Many biological problems are understudied due to experimental limitations and human biases. Although deep learning is promising in accelerating scientific discovery, its power compromises when applied to problems with scarcely labeled data and data d...

An Explainable Graph Neural Framework to Identify Cancer-Associated Intratumoral Microbial Communities.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Microbes are extensively present among various cancer tissues and play critical roles in carcinogenesis and treatment responses. However, the underlying relationships between intratumoral microbes and tumors remain poorly understood. Here, a MIcrobia...

Machine learning surveillance of foodborne infectious diseases using wastewater microbiome, crowdsourced, and environmental data.

Water research
Clostridium perfringens (CP) is a common cause of foodborne infection, leading to significant human health risks and a high economic burden. Thus, effective CP disease surveillance is essential for preventive and therapeutic interventions; however, c...

Using machine learning to identify environmental factors that collectively determine microbial community structure of activated sludge.

Environmental research
Activated sludge (AS) microbial communities are influenced by various environmental variables. However, a comprehensive analysis of how these variables jointly and nonlinearly shape the AS microbial community remains challenging. In this study, we em...

Ensemble learning algorithms to elucidate the core microbiome's impact on carbon content and degradation properties at the soil aggregate level.

The Science of the total environment
Soil aggregates are crucial for soil organic carbon (OC) accumulation. This study, utilizing a 32-year fertilization experiment, investigates whether the core microbiome can elucidate variations in carbon content and decomposition across different ag...