AIMC Topic: Middle Aged

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Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.

Nature communications
Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment response are lacking. Here we analyse RNA-sequencing (RNA-Seq) of pre-treatment synovial tissue from the...

Multimodal nomogram integrating deep learning radiomics and hemodynamic parameters for early prediction of post-craniotomy intracranial hypertension.

Scientific reports
To evaluate the effectiveness of deep learning radiomics nomogram in distinguishing early intracranial hypertension (IH) following primary decompressive craniectomy (DC) in patients with severe traumatic brain injury (TBI) and to demonstrate its pote...

Design of a Mobile App and a Clinical Trial Management System for Cognitive Health and Dementia Risk Reduction: User-Centered Design Approach.

JMIR aging
BACKGROUND: The rising prevalence of dementia is a major concern, with approximately 45% of cases linked to 14 modifiable risk factors. The European project LETHE aims to develop a personalized digital intervention model to delay or prevent cognitive...

A deep learning-based computed tomography reading system for the diagnosis of lung cancer associated with cystic airspaces.

Scientific reports
To propose a deep learning model and explore its performance in the auxiliary diagnosis of lung cancer associated with cystic airspaces (LCCA) in computed tomography (CT) images. This study is a retrospective analysis that incorporated a total of 342...

Assessment of drug induced hyperuricemia and gout risk using the FDA adverse event reporting system.

Scientific reports
Hyperuricemia, the key pathological basis of gout, is increasingly prevalent worldwide. While lifestyle factors contribute, various medications also play a role. However, their specific risks and mechanisms remain inadequately studied. Disproportiona...

Combining multi-parametric MRI radiomics features with tumor abnormal protein to construct a machine learning-based predictive model for prostate cancer.

Scientific reports
This study aims to investigate the diagnostic value of integrating multi-parametric magnetic resonance imaging (mpMRI) radiomic features with tumor abnormal protein (TAP) and clinical characteristics for diagnosing prostate cancer. A cohort of 109 pa...

Developing transferable and universal IR biomarkers for intraoperative colorectal cancer diagnosis via FTIR spectroscopy.

Scientific reports
Histological staining has long been the gold standard for cancer detection, but it is limited by subjectivity and delayed results. Fourier Transform Infrared Spectroscopy (FTIR) has emerged as a promising technique, offering the advantages of objecti...

The impact of intelligent devices utilization on household medical expenditure of older adults in China.

Scientific reports
With the rapid development of artificial intelligence, there is an increasing utilization of intelligent devices by older adults. The relationship between the utilization of intelligent devices and household medical expenditure has garnered widesprea...

Detection of fasting blood sugar using a microwave sensor and convolutional neural network.

Scientific reports
Monitoring of fasting blood sugar (FBS) is a critical component in the diagnosis and management of diabetes, one of the most widespread chronic diseases globally. Microwave sensing-particularly through microstrip-based sensors-has recently gained att...

A deep learning model for diagnosis of inherited retinal diseases.

Scientific reports
To evaluate the performance of a multi-input deep learning (DL) model in detecting two common inherited retinal diseases (IRDs), i.e. retinitis pigmentosa (RP) and Stargardt disease (STGD), and differentiating them from healthy eyes. This cross-secti...