AIMC Topic: Models, Animal

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Automated detection of the head-twitch response using wavelet scalograms and a deep convolutional neural network.

Scientific reports
Hallucinogens induce the head-twitch response (HTR), a rapid reciprocal head movement, in mice. Although head twitches are usually identified by direct observation, they can also be assessed using a head-mounted magnet and a magnetometer. Procedures ...

A Deep Learning Approach for Automated Sleep-Wake Scoring in Pre-Clinical Animal Models.

Journal of neuroscience methods
BACKGROUND: Experimental investigation of sleep-wake dynamics in animals is an important part of pharmaceutical development. Typically, it involves recording of electroencephalogram, electromyogram, locomotor activity, and electrooculogram. Visual id...

Advantages of aquatic animals as models for bio-inspired drones over present AUV technology.

Bioinspiration & biomimetics
Robotic systems are becoming more ubiquitous, whether on land, in the air, or in water. In the aquatic realm, aquatic drones including ROVs (remotely operated vehicles) and AUVs (autonomous underwater vehicles) have opened new opportunities to invest...

WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans.

GeroScience
Caenorhabditis elegans is a popular organism for aging research owing to its highly conserved molecular pathways, short lifespan, small size, and extensive genetic and reverse genetic resources. Here we describe the WormBot, an open-source robotic im...

A null model of the mouse whole-neocortex micro-connectome.

Nature communications
In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-s...

Quantifying ultrasonic mouse vocalizations using acoustic analysis in a supervised statistical machine learning framework.

Scientific reports
Examination of rodent vocalizations in experimental conditions can yield valuable insights into how disease manifests and progresses over time. It can also be used as an index of social interest, motivation, emotional development or motor function de...

Reduction of operator radiation exposure using a passive robotic device during fluoroscopy-guided arterial puncture: an experimental study in a swine model.

European radiology experimental
BACKGROUND: Vascular interventions imply radiation exposure to the operating physician (OP). To reduce radiation exposure, we propose a novel passive robotic device for fluoroscopy-guided arterial puncturing.

High-field mr diffusion-weighted image denoising using a joint denoising convolutional neural network.

Journal of magnetic resonance imaging : JMRI
BACKGROUND: Low signal-to-noise ratio (SNR) has been a major limiting factor for the application of higher-resolution diffusion-weighted imaging (DWI). Most of the conventional denoising models suffer from the drawbacks of shallow feature extraction ...

SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species.

PLoS computational biology
Understanding sleep and its perturbation by environment, mutation, or medication remains a central problem in biomedical research. Its examination in animal models rests on brain state analysis via classification of electroencephalographic (EEG) sign...