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Models, Statistical

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Protein structure modeling and refinement by global optimization in CASP12.

Proteins Dec 5, 2017
For protein structure modeling in the CASP12 experiment, we have developed a new protocol based on our previous CASP11 approach. The global optimization method of conformational space annealing (CSA) was applied to 3 stages of modeling: multiple sequ...
Algorithms Computational Biology Support Vector Machine Models, Statistical Humans Machine Learning Protein Conformation Protein Folding Sequence Analysis, Protein Protein Interaction Domains and Motifs Proteins Models, Molecular Molecular Dynamics Simulation Crystallography, X-Ray
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Efficient Active Sensing with Categorized Further Explorations for a Home Behavior-Monitoring Robot.

Journal of healthcare engineering Nov 28, 2017
Mobile robotics is a potential solution to home behavior monitoring for the elderly. For a mobile robot in the real world, there are several types of uncertainties for its perceptions, such as the ambiguity between a target object and the surrounding...
Health Behavior Monitoring, Ambulatory Pattern Recognition, Automated Humans Movement Algorithms Models, Statistical Reproducibility of Results Robotics Aged Signal Processing, Computer-Assisted Cluster Analysis Monitoring, Physiologic
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Meta-Path Methods for Prioritizing Candidate Disease miRNAs.

IEEE/ACM transactions on computational biology and bioinformatics Nov 22, 2017
MicroRNAs (miRNAs) play critical roles in regulating gene expression at post-transcriptional levels. Numerous experimental studies indicate that alterations and dysregulations in miRNAs are associated with important complex diseases, especially cance...
Models, Statistical ROC Curve Humans Systems Biology Neoplasms Databases, Genetic Disease Progression MicroRNAs
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Alcoholism Detection by Data Augmentation and Convolutional Neural Network with Stochastic Pooling.

Journal of medical systems Nov 17, 2017
Alcohol use disorder (AUD) is an important brain disease. It alters the brain structure. Recently, scholars tend to use computer vision based techniques to detect AUD. We collected 235 subjects, 114 alcoholic and 121 non-alcoholic. Among the 235 imag...
Chronic Disease Alcoholism Aged Sensitivity and Specificity Male Middle Aged China Image Processing, Computer-Assisted Models, Statistical Humans Neural Networks, Computer Brain Female
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Gene Prediction in Metagenomic Fragments with Deep Learning.

BioMed research international Nov 8, 2017
Next generation sequencing technologies used in metagenomics yield numerous sequencing fragments which come from thousands of different species. Accurately identifying genes from metagenomics fragments is one of the most fundamental issues in metagen...
Models, Statistical Machine Learning Metagenomics Bacteria Genes, Bacterial Databases, Genetic Sequence Analysis, DNA
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Identifying causal mechanisms in health care interventions using classification tree analysis.

Journal of evaluation in clinical practice Nov 3, 2017
RATIONALE, AIMS, AND OBJECTIVES: Mediation analysis identifies causal pathways by testing the relationships between the treatment, the outcome, and an intermediate variable that mediates the relationship between the treatment and outcome. This paper ...
Machine Learning Female Adult Male Humans Decision Trees Sex Factors Employment Outcome and Process Assessment, Health Care Middle Aged Depression Age Factors Models, Statistical
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Collaborative targeted learning using regression shrinkage.

Statistics in medicine Nov 2, 2017
Causal inference practitioners are routinely presented with the challenge of model selection and, in particular, reducing the size of the covariate set with the goal of improving estimation efficiency. Collaborative targeted minimum loss-based estima...
Biostatistics Asthma Causality Models, Statistical Computer Simulation Regression Analysis Outcome Assessment, Health Care Pregnancy Pregnancy Complications Female Humans Propensity Score Infant, Newborn Machine Learning Likelihood Functions Algorithms
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Supervised learning techniques and their ability to classify a change of direction task strategy using kinematic and kinetic features.

Journal of biomechanics Oct 31, 2017
This study examines the ability of commonly used supervised learning techniques to classify the execution of a maximum effort change of direction task into predefined movement pattern as well as the influence of fuzzy executions and the impact of sel...
Bayes Theorem Discriminant Analysis Rotation Range of Motion, Articular Hip Joint Humans Ankle Joint Sports Male Support Vector Machine Models, Statistical Decision Trees Young Adult Adult Biomechanical Phenomena Movement Ankle
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Maximum entropy methods for extracting the learned features of deep neural networks.

PLoS computational biology Oct 30, 2017
New architectures of multilayer artificial neural networks and new methods for training them are rapidly revolutionizing the application of machine learning in diverse fields, including business, social science, physical sciences, and biology. Interp...
Models, Statistical Pattern Recognition, Automated Entropy Machine Learning Algorithms Computer Simulation Sequence Analysis, DNA Neural Networks, Computer
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Deep Learning Based Regression and Multiclass Models for Acute Oral Toxicity Prediction with Automatic Chemical Feature Extraction.

Journal of chemical information and modeling Oct 27, 2017
Median lethal death, LD, is a general indicator of compound acute oral toxicity (AOT). Various in silico methods were developed for AOT prediction to reduce costs and time. In this study, we developed an improved molecular graph encoding convolutiona...
Toxicity Tests Lethal Dose 50 Informatics Machine Learning Models, Statistical Regression Analysis Administration, Oral Automation
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