AIMC Topic: Mucocutaneous Lymph Node Syndrome

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Plasma cell-free RNA signatures of inflammatory syndromes in children.

Proceedings of the National Academy of Sciences of the United States of America Sep 6, 2024
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circul...
Male Infant Adolescent Humans Child, Preschool Machine Learning COVID-19 Biomarkers Female Mucocutaneous Lymph Node Syndrome Diagnosis, Differential Child Bacterial Infections Systemic Inflammatory Response Syndrome Virus Diseases Inflammation Cell-Free Nucleic Acids
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Intelligent diagnosis of Kawasaki disease from real-world data using interpretable machine learning models.

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese Aug 10, 2024
OBJECTIVE: This study aimed to leverage real-world electronic medical record data to develop interpretable machine learning models for diagnosis of Kawasaki disease while also exploring and prioritizing the significant risk factors.
Male Infant China Child, Preschool Machine Learning Child Electronic Health Records Humans ROC Curve Female Mucocutaneous Lymph Node Syndrome Risk Factors
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Prediction Models for Intravenous Immunoglobulin Non-Responders of Kawasaki Disease Using Machine Learning.

Clinical drug investigation Jun 13, 2024
BACKGROUND AND OBJECTIVE: Intravenous immunoglobulin (IVIG) is a prominent therapeutic agent for Kawasaki disease (KD) that significantly reduces the incidence of coronary artery anomalies. Various methodologies, including machine learning, have been...
Humans Infant Child, Preschool Child Mucocutaneous Lymph Node Syndrome Machine Learning Retrospective Studies Female Male Immunoglobulins, Intravenous Prednisolone
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Development of an immunoinflammatory indicator-related dynamic nomogram based on machine learning for the prediction of intravenous immunoglobulin-resistant Kawasaki disease patients.

International immunopharmacology May 3, 2024
BACKGROUND: Approximately 10-20% of Kawasaki disease (KD) patients suffer from intravenous immunoglobulin (IVIG) resistance, placing them at higher risk of developing coronary artery aneurysms. Therefore, we aimed to construct an IVIG resistance pred...
C-Reactive Protein Immunoglobulins, Intravenous Drug Resistance Child, Preschool Child Nomograms Mucocutaneous Lymph Node Syndrome Humans Machine Learning Retrospective Studies Female Male Infant China
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A simple scoring model based on machine learning predicts intravenous immunoglobulin resistance in Kawasaki disease.

Clinical rheumatology Jan 11, 2023
INTRODUCTION: In Kawasaki disease (KD), accurate prediction of intravenous immunoglobulin (IVIG) resistance is crucial to reduce a risk for developing coronary artery lesions.
Drug Resistance Retrospective Studies ROC Curve Mucocutaneous Lymph Node Syndrome Immunoglobulins, Intravenous Humans Machine Learning
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Explainable deep learning algorithm for distinguishing incomplete Kawasaki disease by coronary artery lesions on echocardiographic imaging.

Computer methods and programs in biomedicine Jun 21, 2022
BACKGROUND AND OBJECTIVE: Incomplete Kawasaki disease (KD) has often been misdiagnosed due to a lack of the clinical manifestations of classic KD. However, it is associated with a markedly higher prevalence of coronary artery lesions. Identifying cor...
Coronary Vessels Algorithms Humans Echocardiography Child COVID-19 Infant Mucocutaneous Lymph Node Syndrome Deep Learning Coronary Artery Disease Fever
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Deep Learning-Based Approach to Automatically Assess Coronary Distensibility Following Kawasaki Disease.

Pediatric cardiology Dec 2, 2021
Kawasaki disease is an acute vasculitis affecting children, which can lead to coronary artery (CA) aneurysms. Optical coherence tomography (OCT) has identified CA wall damage in KD patients, but it is unclear if these findings correlate with any dist...
Humans Coronary Vessels Deep Learning Coronary Aneurysm Child Mucocutaneous Lymph Node Syndrome Coronary Angiography
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A machine learning approach to predict intravenous immunoglobulin resistance in Kawasaki disease patients: A study based on a Southeast China population.

PloS one Aug 27, 2020
Kawasaki disease is the leading cause of pediatric acquired heart disease. Coronary artery abnormalities are the main complication of Kawasaki disease. Kawasaki disease patients with intravenous immunoglobulin resistance are at a greater risk of deve...
Drug Resistance Male Risk Assessment Infant China Retrospective Studies Female Risk Factors Coronary Artery Disease Feasibility Studies Humans Models, Biological Child, Preschool Machine Learning Immunoglobulins, Intravenous ROC Curve Logistic Models Mucocutaneous Lymph Node Syndrome
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Structure equation model and neural network analyses to predict coronary artery lesions in Kawasaki disease: a single-centre retrospective study.

Scientific reports Jul 17, 2020
A new method to predict coronary artery lesions (CALs) in Kawasaki disease (KD) was developed using a mean structure equation model (SEM) and neural networks (Nnet). There were 314 admitted children with KD who met at least four of the six diagnostic...
Adult Sensitivity and Specificity Male Models, Statistical Mucocutaneous Lymph Node Syndrome Coronary Artery Disease Disease Susceptibility Biomarkers Prognosis Retrospective Studies Female Humans Neural Networks, Computer
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Role of Antioxidants in Horse Serum-mediated Vasculitis in Swine: Potential Relevance to Early Treatment in Mitigation of Coronary Arteritis in Kawasaki Disease.

Pediatrics and neonatology Dec 18, 2016
BACKGROUND: Horse serum-induced immune complex coronary vasculitis in swine is the first experimental model to mimic most of the pictures of Kawasaki disease. Immune complex mechanism has been implicated as one of the possible mechanisms in the patho...
Coronary Artery Disease Immunologic Factors Body Weight Vasculitis Antioxidants Immunoglobulins, Intravenous Animals Disease Models, Animal Antigen-Antibody Complex Male Mucocutaneous Lymph Node Syndrome Swine Vitamins
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