AIMC Topic: Mutation

Clear Filters Showing 461 to 470 of 651 articles

Document triage for identifying protein-protein interactions affected by mutations: a neural network ensemble approach.

Database : the journal of biological databases and curation Jan 1, 2018
The precision medicine (PM) initiative promises to identify individualized treatment depending on a patients' genetic profile and their related responses. In order to help health professionals and researchers in the PM endeavor, BioCreative VI organi...
Databases, Protein Mutation Neural Networks, Computer Algorithms Protein Interaction Maps
View on PubMed DOI

An end-to-end deep learning architecture for extracting protein-protein interactions affected by genetic mutations.

Database : the journal of biological databases and curation Jan 1, 2018
The BioCreative VI Track IV (mining protein interactions and mutations for precision medicine) challenge was organized in 2017 with the goal of applying biomedical text mining methods to support advancements in precision medicine approaches. As part ...
Algorithms Protein Interaction Maps Neural Networks, Computer Databases, Protein Machine Learning Mutation
View on PubMed DOI

Hierarchical bi-directional attention-based RNNs for supporting document classification on protein-protein interactions affected by genetic mutations.

Database : the journal of biological databases and curation Jan 1, 2018
In this paper, we describe a hierarchical bi-directional attention-based Re-current Neural Network (RNN) as a reusable sequence encoder architecture, which is used as sentence and document encoder for document classification. The sequence encoder is ...
Models, Theoretical Support Vector Machine Databases, Protein Mutation Data Mining Neural Networks, Computer Algorithms Reproducibility of Results Protein Interaction Maps
View on PubMed DOI

A case of apolipoprotein A-I deficiency due to carboxyl-terminal truncation.

Journal of clinical lipidology Dec 29, 2017
Apolipoprotein A-I deficiency is a rare metabolic disease characterized by an impaired reverse cholesterol transport system resulting in excessive cholesterol accumulation. Here, we discuss a case of apolipoprotein A-I deficiency caused by a carboxyl...
Aged Mutation Apolipoprotein A-I Cholesterol Family Health Base Sequence Pedigree Cholesterol, HDL DNA Mutational Analysis Exome Sequencing Humans Female
View on PubMed DOI

Variants in GNPTAB, GNPTG and NAGPA genes are associated with stutterers.

Gene Dec 28, 2017
Non-syndromic stuttering is a neurodevelopmental disorder characterized by disruptions in normal flow of speech in the form of repetition, prolongation and involuntary halts. Previously, mutations with more severe effects on GNPTAB and GNPTG have bee...
Phosphoric Diester Hydrolases Stuttering Transferases (Other Substituted Phosphate Groups) Humans Heterozygote Phenotype Homozygote Female Introns Male Mucolipidoses Child Child, Preschool Genetic Predisposition to Disease Mutation
View on PubMed DOI

Classifying cancer genome aberrations by their mutually exclusive effects on transcription.

BMC medical genomics Dec 21, 2017
BACKGROUND: Malignant tumors are typically caused by a conglomeration of genomic aberrations-including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemotherapies and targeted drug trea...
Transcription, Genetic Humans Machine Learning Neoplasms Lung Neoplasms Adenocarcinoma Mutation Genome, Human
View on PubMed DOI

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.

Haematologica Dec 14, 2017
Primary therapy resistance is a major problem in acute myeloid leukemia treatment. We set out to develop a powerful and robust predictor for therapy resistance for intensively treated adult patients. We used two large gene expression data sets (n=856...
Humans Machine Learning Prognosis Female Aged Randomized Controlled Trials as Topic Predictive Value of Tests Mutation Aged, 80 and over Male Remission Induction Survival Analysis Young Adult Middle Aged Adult Drug Resistance, Neoplasm Gene Expression Profiling Leukemia, Myeloid, Acute Adolescent
View on PubMed DOI

Residual Convolutional Neural Network for the Determination of Status in Low- and High-Grade Gliomas from MR Imaging.

Clinical cancer research : an official journal of the American Association for Cancer Research Nov 22, 2017
Isocitrate dehydrogenase () mutations in glioma patients confer longer survival and may guide treatment decision making. We aimed to predict the status of gliomas from MR imaging by applying a residual convolutional neural network to preoperative r...
Glioma Magnetic Resonance Imaging Predictive Value of Tests Neoplasm Grading Brain Neoplasms Male Middle Aged Image Processing, Computer-Assisted Mutation Datasets as Topic Preoperative Period Isocitrate Dehydrogenase Neural Networks, Computer Brain Retrospective Studies Female Aged Aged, 80 and over Young Adult Adult Humans
View on PubMed DOI

MRI features predict p53 status in lower-grade gliomas via a machine-learning approach.

NeuroImage. Clinical Oct 29, 2017
BACKGROUND: P53 mutation status is a pivotal biomarker for gliomas. Here, we developed a machine-learning model to predict p53 status in lower-grade gliomas based on radiomic features extracted from conventional magnetic resonance (MR) images.
Mutation Tumor Suppressor Protein p53 ROC Curve Humans Image Processing, Computer-Assisted Machine Learning Male Aged Adolescent Retrospective Studies Glioma Middle Aged Young Adult Female Magnetic Resonance Imaging Child, Preschool Adult Child Brain Neoplasms
View on PubMed DOI

Multi-label Inductive Matrix Completion for Joint MGMT and IDH1 Status Prediction for Glioma Patients.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention Sep 4, 2017
MGMT promoter methylation and IDH1 mutation in high-grade gliomas (HGG) have proven to be the two important molecular indicators associated with better prognosis. Traditionally, the statuses of MGMT and IDH1 are obtained via surgical biopsy, which is...
Sensitivity and Specificity DNA Repair Enzymes Glioma Humans Tumor Suppressor Proteins Reproducibility of Results Brain Neoplasms DNA Methylation Connectome Aged Male Mutation Isocitrate Dehydrogenase Algorithms Young Adult Middle Aged DNA Modification Methylases Prognosis Adult Female
View on PubMed DOI
Popular Topics
Recent Journals