AIMC Topic: Nanoparticles

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Exploring therapeutic and diagnostic potential of cysteine cathepsin as targets for cancer therapy with nanomedicine.

International journal of biological macromolecules
Cysteine cathepsins have been discovered to be substantially expressed in multiple types of cancer. They play a key role in the progression and growth of these cancers, rendering them appealing targets for nanoscale delivery and noninvasive diagnosti...

Intelligent deep learning model for targeted cancer drug delivery.

Scientific reports
Nanotechnology and information communication technology (ICT) are being combined to develop innovative drug delivery systems for targeted sites, such as tumor cells. The particulate targeted drug delivery (PTDD) system involves drugs containing nanop...

Machine-Learning Framework to Predict the Performance of Lipid Nanoparticles for Nucleic Acid Delivery.

ACS applied bio materials
Lipid nanoparticles (LNPs) are highly effective carriers for gene therapies, including mRNA and siRNA delivery, due to their ability to transport nucleic acids across biological membranes, low cytotoxicity, improved pharmacokinetics, and scalability....

Active Learning-Based Prediction of Drug Combination Efficacy.

ACS nano
Combination therapy, which involves the use of multiple drugs, has emerged as a promising approach to cancer treatment. However, traditional combination therapy development is constrained by the vast experimental design space, requiring exhaustive te...

Machine Learning Advancements and Strategies in Microplastic and Nanoplastic Detection.

Environmental science & technology
Microplastics (MPs) and nanoplastics (NPs) present formidable global environmental challenges with serious risks to human health and ecosystem sustainability. Despite their significance, the accurate assessment of environmental MP and NP pollution re...

Intelligent Olfactory System Utilizing Ceria Nanoparticle-Integrated Laser-Induced Graphene.

ACS nano
The digitization of human senses has driven innovation across various technologies and transformed our daily lives, yet the digitization of olfaction remains a challenging frontier. Artificial olfactory systems, or electronic noses (e-noses), offer g...

Lipid nanoparticle (LNP) mediated mRNA delivery in neurodegenerative diseases.

Journal of controlled release : official journal of the Controlled Release Society
Neurodegenerative diseases (NDD) are characterized by the progressive loss of neurons and the impairment of cellular functions. Messenger RNA (mRNA) has emerged as a promising therapy for treating NDD, as it can encode missing or dysfunctional protei...

Bioconjugates of photon-upconversion nanoparticles with antibodies for the detection of prostate-specific antigen and p53 in heterogeneous and homogeneous immunoassays.

Nanoscale
Sensitive immunoassays for the detection of tumor biomarkers play an important role in the early diagnosis and therapy of cancer. Using luminescent nanomaterials as labels can significantly improve immunoassay performance, especially in terms of sens...

Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.

Molecular cancer therapeutics
The treatment of primary central nervous system tumors is challenging due to the blood-brain barrier and complex mutational profiles, which is associated with low survival rates. However, recent studies have identified common mutations in gliomas [is...

Understanding the Manufacturing Process of Lipid Nanoparticles for mRNA Delivery Using Machine Learning.

Chemical & pharmaceutical bulletin
Lipid nanoparticles (LNPs), used for mRNA vaccines against severe acute respiratory syndrome coronavirus 2, protect mRNA and deliver it into cells, making them an essential delivery technology for RNA medicine. The LNPs manufacturing process consists...