AIMC Topic: Neoplasms

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Drug discovery and mechanism prediction with explainable graph neural networks.

Scientific reports
Apprehension of drug action mechanism is paramount for drug response prediction and precision medicine. The unprecedented development of machine learning and deep learning algorithms has expedited the drug response prediction research. However, exist...

A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing.

Nature communications
Microsatellite instability (MSI) is a critical phenotype of cancer genomes and an FDA-recognized biomarker that can guide treatment with immune checkpoint inhibitors. Previous work has demonstrated that next-generation sequencing data can be used to ...

Multi-Modal Federated Learning for Cancer Staging Over Non-IID Datasets With Unbalanced Modalities.

IEEE transactions on medical imaging
The use of machine learning (ML) for cancer staging through medical image analysis has gained substantial interest across medical disciplines. When accompanied by the innovative federated learning (FL) framework, ML techniques can further overcome pr...

FR-MIL: Distribution Re-Calibration-Based Multiple Instance Learning With Transformer for Whole Slide Image Classification.

IEEE transactions on medical imaging
In digital pathology, whole slide images (WSI) are crucial for cancer prognostication and treatment planning. WSI classification is generally addressed using multiple instance learning (MIL), alleviating the challenge of processing billions of pixels...

Spatially-Constrained and -Unconstrained Bi-Graph Interaction Network for Multi-Organ Pathology Image Classification.

IEEE transactions on medical imaging
In computational pathology, graphs have shown to be promising for pathology image analysis. There exist various graph structures that can discover differing features of pathology images. However, the combination and interaction between differing grap...

An appropriate DNA input for bisulfite conversion reveals LINE-1 and Alu hypermethylation in tissues and circulating cell-free DNA from cancers.

PloS one
The autonomous and active Long-Interspersed Element-1 (LINE-1, L1) and the non-autonomous Alu retrotransposon elements, contributing to 30% of the human genome, are the most abundant repeated sequences. With more than 90% of their sequences being met...

Comparative evaluation of feature reduction methods for drug response prediction.

Scientific reports
Personalized medicine aims to tailor medical treatments to individual patients, and predicting drug responses from molecular profiles using machine learning is crucial for this goal. However, the high dimensionality of the molecular profiles compared...

Development of a Predictive Model of Occult Cancer After a Venous Thromboembolism Event Using Machine Learning: The CLOVER Study.

Medicina (Kaunas, Lithuania)
: Venous thromboembolism (VTE) can be the first manifestation of an underlying cancer. This study aimed to develop a predictive model to assess the risk of occult cancer between 30 days and 24 months after a venous thrombotic event using machine lear...

AI-Enhanced Healthcare: Integrating ChatGPT-4 in ePROs for Improved Oncology Care and Decision-Making: A Pilot Evaluation.

Current oncology (Toronto, Ont.)
BACKGROUND: Since 2023, ChatGPT-4 has been impactful across several sectors including healthcare, where it aids in medical information analysis and education. Electronic patient-reported outcomes (ePROs) play a crucial role in monitoring cancer patie...

Precision in Parsing: Evaluation of an Open-Source Named Entity Recognizer (NER) in Veterinary Oncology.

Veterinary and comparative oncology
Integrating Artificial Intelligence (AI) through Natural Language Processing (NLP) can improve veterinary medical oncology clinical record analytics. Named Entity Recognition (NER), a critical component of NLP, can facilitate efficient data extractio...