BACKGROUND: Immune checkpoint inhibitors (ICIs) are essential first-line treatments for recurrent or metastatic non-small cell lung cancer (NSCLC). However, predicting their effectiveness and the occurrence of immunotherapy-related adverse events (ir...
Journal of chemical information and modeling
Jul 25, 2025
Machine learning has become an essential tool in computational drug design, enabling models to uncover patterns in molecular data and predict protein-ligand interactions. This study introduces a novel approach by integrating persistence images with M...
Journal of chemical information and modeling
Jul 25, 2025
Molecular carcinogenicity is a crucial factor in the development of cancer, and accurate prediction of it is vital for cancer prevention, treatment, and drug development. In recent years, deep learning has been applied to predict molecular carcinogen...
Micro- and nanoplastics (MNPs) are emerging pollutants that accumulate in ecosystems, food chains, and the human body, raising concerns about human health risks. However, understanding their toxicity remains challenging due to limited experimental da...
A significant obstacle in brain tumor treatment planning is determining the tumor's actual size. Magnetic resonance imaging (MRI) is one of the first-line brain tumor diagnosis. It takes a lot of effort and mostly depends on the operator's experience...
Moving from a one-size-fits-all to an individual approach in precision medicine requires a deeper understanding of disease molecular mechanisms. Especially in heterogeneous complex diseases such as inflammatory bowel disease (IBD), better molecular s...
We propose a mathematical framework to systematically explore the propagation properties of a class of continuous in time nonlinear neural network models comprising a hierarchy of processing areas, mutually connected according to the principles of pr...
Potato as a staple food, plays a crucial role in ensuring a sustainable food supply and mitigating poverty and malnutrition in various regions across the globe. India, specifically holding the second position in global potato production, plays a sign...
The process of protein aggregation, central to neurodegenerative diseases like Huntington's, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in d...
Porcine epidemic diarrhea is a highly contagious intestinal disease in pigs, caused by various strains of porcine epidemic diarrhea virus (PEDV). The infection rate in suckling piglets can reach 100%. Manual analysis of pathological images is the pri...
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