AIMC Topic: Oligonucleotide Array Sequence Analysis

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CGPS: A machine learning-based approach integrating multiple gene set analysis tools for better prioritization of biologically relevant pathways.

Journal of genetics and genomics = Yi chuan xue bao
Gene set enrichment (GSE) analyses play an important role in the interpretation of large-scale transcriptome datasets. Multiple GSE tools can be integrated into a single method as obtaining optimal results is challenging due to the plethora of GSE to...

Novel symmetry-based gene-gene dissimilarity measures utilizing Gene Ontology: Application in gene clustering.

Gene
In recent years DNA microarray technology, leading to the generation of high-volume biological data, has gained significant attention. To analyze this high volume gene-expression data, one such powerful tool is Clustering. For any clustering algorith...

CEA: Combination-based gene set functional enrichment analysis.

Scientific reports
Functional enrichment analysis is a fundamental and challenging task in bioinformatics. Most of the current enrichment analysis approaches individually evaluate functional terms and often output a list of enriched terms with high similarity and redun...

Learning a single-hidden layer feedforward neural network using a rank correlation-based strategy with application to high dimensional gene expression and proteomic spectra datasets in cancer detection.

Journal of biomedical informatics
Methods based on microarrays (MA), mass spectrometry (MS), and machine learning (ML) algorithms have evolved rapidly in recent years, allowing for early detection of several types of cancer. A pitfall of these approaches, however, is the overfitting ...

An Efficient Mixed-Model for Screening Differentially Expressed Genes of Breast Cancer Based on LR-RF.

IEEE/ACM transactions on computational biology and bioinformatics
To screen differentially expressed genes quickly and efficiently in breast cancer, two gene microarray datasets of breast cancer, GSE15852 and GSE45255, were downloaded from GEO. By combining the Logistic Regression and Random Forest algorithm, this ...

Fuzzy Expert System based on a Novel Hybrid Stem Cell (HSC) Algorithm for Classification of Micro Array Data.

Journal of medical systems
In the growing scenario, microarray data is extensively used since it provides a more comprehensive understanding of genetic variants among diseases. As the gene expression samples have high dimensionality it becomes tedious to analyze the samples ma...

Functional Categorization of Disease Genes Based on Spectral Graph Theory and Integrated Biological Knowledge.

Interdisciplinary sciences, computational life sciences
Interaction of multiple genetic variants is a major challenge in the development of effective treatment strategies for complex disorders. Identifying the most promising genes enhances the understanding of the underlying mechanisms of the disease, whi...

Serum microRNA panel excavated by machine learning as a potential biomarker for the detection of gastric cancer.

Oncology reports
Early detection of gastric cancer (GC) is crucial to improve the therapeutic effect and prolong the survival of patients. MicroRNAs (miRNAs) are a group of small non-protein-coding RNAs that function as repressors of diverse genes. We aimed to identi...

Effect of abiotic and biotic stress factors analysis using machine learning methods in zebrafish.

Comparative biochemistry and physiology. Part D, Genomics & proteomics
In order to understand the mechanisms underlying stress responses, meta-analysis of transcriptome is made to identify differentially expressed genes (DEGs) and their biological, molecular and cellular mechanisms in response to stressors. The present ...

Incorporating gene ontology into fuzzy relational clustering of microarray gene expression data.

Bio Systems
The product of gene expression works together in the cell for each living organism in order to achieve different biological processes. Many proteins are involved in different roles depending on the environment of the organism for the functioning of t...