AIMC Topic: Oxidoreductases

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Multiclassification Prediction of Enzymatic Reactions for Oxidoreductases and Hydrolases Using Reaction Fingerprints and Machine Learning Methods.

Journal of chemical information and modeling May 21, 2018
Drug metabolism is a complex procedure in the human body, including a series of enzymatically catalyzed reactions. However, it is costly and time consuming to investigate drug metabolism experimentally; computational methods are hence developed to pr...
Hydrolases Animals Oxidoreductases Oxidation-Reduction Neural Networks, Computer Models, Biological Biocatalysis Machine Learning Computer Simulation Pharmaceutical Preparations Humans
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Antileishmanial activity of novel indolyl-coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction.

Bioorganic & medicinal chemistry letters Dec 24, 2015
In present work we have designed and synthesized total twelve novel 3-(3-(1H-indol-3-yl)-3-phenylpropanoyl)-4-hydroxy-2H-chromen-2-one derivatives 13(a-l) using Ho(3+) doped CoFe2O4 nanoparticles as catalyst and evaluated for their potential antileis...
Binding Sites Leishmania Structure-Activity Relationship Protozoan Proteins Enzyme Inhibitors HeLa Cells Coumarins Protein Structure, Tertiary Humans Oxidoreductases Antiprotozoal Agents Molecular Docking Simulation Inhibitory Concentration 50 Antioxidants Cell Survival Drug Design
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Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Nutrition research (New York, N.Y.) Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Biological Products Polyphenols Acetates Polysaccharides Nerve Tissue Proteins Plant Extracts Neuroprotective Agents Apoptosis Oxidative Stress Brain Antioxidants Humans Republic of Korea Neurons Medicine, Korean Traditional Basidiomycota Gene Expression Regulation, Enzymologic Ethnopharmacology Cell Line, Tumor MAP Kinase Signaling System Solvents Fruiting Bodies, Fungal Phellinus Oxidoreductases
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Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models.

Molecular biology reports Feb 4, 2015
Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene-gene interactions among these two metabolic pathways in four disea...
Coronary Artery Disease Sex Factors Datasets as Topic Factor Analysis, Statistical Lupus Erythematosus, Systemic Oxidoreductases Transferases Multifactor Dimensionality Reduction Gene Expression Regulation Epistasis, Genetic Genetic Predisposition to Disease Polymorphism, Single Nucleotide Parkinson Disease Metabolic Networks and Pathways Carbon Breast Neoplasms Male Case-Control Studies Humans Female Xenobiotics
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CHCHD4 Oxidoreductase Activity: A Comprehensive Analysis of the Molecular, Functional, and Structural Properties of Its Redox-Regulated Substrates.

Molecules (Basel, Switzerland) May 10, 2025
The human CHCHD4 protein, which is a prototypical family member, carries a coiled-coil-helix-coiled-coil-helix motif that is stabilized by two disulfide bonds. Using its CPC sequence motif, CHCHD4 plays a key role in mitochondrial metabolism, cell su...
Humans Oxidation-Reduction Models, Molecular Oxidoreductases Mitochondrial Proteins Mitochondrial Precursor Protein Import Complex Proteins Mitochondria Substrate Specificity
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