AIMC Topic: Phenotype

Clear Filters Showing 641 to 650 of 922 articles

Inter-labeler and intra-labeler variability of condition severity classification models using active and passive learning methods.

Artificial intelligence in medicine Apr 27, 2017
BACKGROUND AND OBJECTIVES: Labeling instances by domain experts for classification is often time consuming and expensive. To reduce such labeling efforts, we had proposed the application of active learning (AL) methods, introduced our CAESAR-ALE fram...
Time Factors Area Under Curve Supervised Machine Learning Electronic Health Records Reproducibility of Results Severity of Illness Index Data Mining Observer Variation Learning Curve Humans Phenotype
View on PubMed DOI

Learning from biomedical linked data to suggest valid pharmacogenes.

Journal of biomedical semantics Apr 20, 2017
BACKGROUND: A standard task in pharmacogenomics research is identifying genes that may be involved in drug response variability, i.e., pharmacogenes. Because genomic experiments tended to generate many false positives, computational approaches based ...
Machine Learning Phenotype Pharmacogenetics Semantic Web Computational Biology Data Mining Computer Graphics
View on PubMed DOI

EHR-based phenotyping: Bulk learning and evaluation.

Journal of biomedical informatics Apr 12, 2017
In data-driven phenotyping, a core computational task is to identify medical concepts and their variations from sources of electronic health records (EHR) to stratify phenotypic cohorts. A conventional analytic framework for phenotyping largely uses ...
Electronic Health Records Models, Statistical Supervised Machine Learning Data Curation Humans Phenotype
View on PubMed DOI

SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature.

Journal of biomedical semantics Apr 7, 2017
BACKGROUND: Single Nucleotide Polymorphisms (SNPs) are among the most important types of genetic variations influencing common diseases and phenotypes. Recently, some corpora and methods have been developed with the purpose of extracting mutations an...
Gene Ontology Mutation Information Storage and Retrieval Semantics Phenotype Polymorphism, Single Nucleotide
View on PubMed DOI

How evolution learns to generalise: Using the principles of learning theory to understand the evolution of developmental organisation.

PLoS computational biology Apr 6, 2017
One of the most intriguing questions in evolution is how organisms exhibit suitable phenotypic variation to rapidly adapt in novel selective environments. Such variability is crucial for evolvability, but poorly understood. In particular, how can nat...
Humans Machine Learning Models, Biological Selection, Genetic Environment Biological Evolution Phenotype Learning Computational Biology
View on PubMed DOI

Computer vision and machine learning for robust phenotyping in genome-wide studies.

Scientific reports Mar 8, 2017
Traditional evaluation of crop biotic and abiotic stresses are time-consuming and labor-intensive limiting the ability to dissect the genetic basis of quantitative traits. A machine learning (ML)-enabled image-phenotyping pipeline for the genetic stu...
Phenotype Genome-Wide Association Study Image Processing, Computer-Assisted Artificial Intelligence Stress, Physiological Machine Learning Glycine max Quantitative Trait Loci
View on PubMed DOI

Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction.

Journal of cardiovascular translational research Mar 3, 2017
We sought to evaluate whether unbiased machine learning of dense phenotypic data ("phenomapping") could identify distinct hypertension subgroups that are associated with the myocardial substrate (i.e., abnormal cardiac mechanics) for heart failure wi...
Heart Failure Pattern Recognition, Automated Stress, Mechanical Echocardiography, Doppler Cluster Analysis Predictive Value of Tests Blood Pressure Risk Assessment United States Hypertension Aged Adult Cross-Sectional Studies Stroke Volume Middle Aged Biomechanical Phenomena Male Prognosis Female Risk Factors Humans Machine Learning Phenotype
View on PubMed DOI

The ontogeny of kin-recognition mechanisms in Belding's ground squirrels.

Physiology & behavior Feb 27, 2017
Despite extensive research on the functions and mechanisms of kin recognition, little is known about developmental changes in the abilities mediating such recognition. Belding's ground squirrels, Urocitellus beldingi, use at least two mechanisms of k...
Phenotype Time Factors Age Factors Odorants Sciuridae Female Animals Biological Ontologies Male Social Behavior Recognition, Psychology
View on PubMed DOI

Tensor Factorization for Precision Medicine in Heart Failure with Preserved Ejection Fraction.

Journal of cardiovascular translational research Jan 23, 2017
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome that may benefit from improved subtyping in order to better characterize its pathophysiology and to develop novel targeted therapies. The United States Precis...
Heart Failure Systems Integration Genetic Predisposition to Disease Systems Biology Predictive Value of Tests Prognosis Echocardiography Machine Learning Risk Factors Comorbidity Humans Stroke Volume Genomics Phenotype Precision Medicine
View on PubMed DOI

Thematic issue of the Second combined Bio-ontologies and Phenotypes Workshop.

Journal of biomedical semantics Dec 12, 2016
This special issue covers selected papers from the 18th Bio-Ontologies Special Interest Group meeting and Phenotype Day, which took place at the Intelligent Systems for Molecular Biology (ISMB) conference in Dublin in 2015. The papers presented in th...
Phenotype Biological Ontologies
View on PubMed DOI
Popular Topics
Recent Journals