AIMC Topic: Polymorphism, Single Nucleotide

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Screening the Best Risk Model and Susceptibility SNPs for Chronic Obstructive Pulmonary Disease (COPD) Based on Machine Learning Algorithms.

International journal of chronic obstructive pulmonary disease Nov 5, 2024
BACKGROUND AND PURPOSE: Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors, and genetic factors are important determinants of COPD. This study focuses on scree...
Logistic Models Pulmonary Disease, Chronic Obstructive Predictive Value of Tests Male Phenotype Middle Aged Humans Genetic Predisposition to Disease Machine Learning Polymorphism, Single Nucleotide Algorithms Risk Assessment Female Genetic Association Studies Lung Risk Factors Case-Control Studies Aged ROC Curve
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Multimodal AI/ML for discovering novel biomarkers and predicting disease using multi-omics profiles of patients with cardiovascular diseases.

Scientific reports Nov 3, 2024
Cardiovascular diseases (CVDs) are complex, multifactorial conditions that require personalized assessment and treatment. Advancements in multi-omics technologies, namely RNA sequencing and whole-genome sequencing, have provided translational researc...
Transcriptome Genomics Polymorphism, Single Nucleotide Computational Biology Cardiovascular Diseases Middle Aged Gene Expression Profiling Multiomics Humans Artificial Intelligence Machine Learning Biomarkers Female Male
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Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4.

Computers in biology and medicine Nov 1, 2024
BACKGROUND: Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed to detect genetic variants associated w...
Male Antineoplastic Agents Adolescent Child, Preschool Humans Machine Learning Female Cisplatin Child Toll-Like Receptor 4 Polymorphism, Single Nucleotide Ototoxicity Membrane Proteins
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Predicting laboratory aspirin resistance in Chinese stroke patients using machine learning models by GP1BA polymorphism.

Pharmacogenomics Oct 23, 2024
This study aims to use machine learning model to predict laboratory aspirin resistance (AR) in Chinese stroke patients by incorporating patient characteristics and single nucleotide polymorphisms of and . 2405 patients were analyzed to measure the M...
Drug Resistance Stroke Aspirin Platelet Aggregation Inhibitors Humans China Machine Learning Polymorphism, Single Nucleotide Genotype Female East Asian People Aged Male Middle Aged
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Phylogenomics and phylogeographic model testing using convolutional neural networks reveal a history of recent admixture in the Canarian Kleinia neriifolia.

Molecular ecology Oct 19, 2024
Multiple-island endemics (MIE) are considered ideal natural subjects to study patterns of island colonization that involve recent population-level genetic processes. Kleinia neriifolia is a Canarian MIE widespread across the archipelago, which exhibi...
Phylogeny Polymorphism, Single Nucleotide Phylogeography Genetics, Population Islands Plastids Neural Networks, Computer
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Gene-diet interactions in carbonated sugar-sweetened beverage consumption and metabolic syndrome risk: A machine learning analysis in a large hospital-based cohort.

Clinical nutrition ESPEN Oct 11, 2024
BACKGROUND AND AIM: Carbonated sugar-sweetened beverages (CSSB) intake has been increasingly linked to metabolic diseases. To investigate the association between CSSB intake and metabolic syndrome (MetS) risk, and the interaction between genetic pred...
Male Middle Aged Diet Genome-Wide Association Study Female Risk Factors Sugar-Sweetened Beverages Humans Adult Feeding Behavior Machine Learning Carbonated Beverages Gene-Environment Interaction Cohort Studies Genetic Predisposition to Disease Polymorphism, Single Nucleotide Metabolic Syndrome
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Analysis of Cancer-Associated Mutations of POLB Using Machine Learning and Bioinformatics.

IEEE/ACM transactions on computational biology and bioinformatics Oct 9, 2024
DNA damage is a critical factor in the onset and progression of cancer. When DNA is damaged, the number of genetic mutations increases, making it necessary to activate DNA repair mechanisms. A crucial factor in the base excision repair process, which...
DNA Polymerase beta Neoplasms Polymorphism, Single Nucleotide Computational Biology Mutation Humans Machine Learning Algorithms
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Enhancing Gene Expression Predictions Using Deep Learning and Functional Annotations.

Genetic epidemiology Sep 30, 2024
Transcriptome-wide association studies (TWAS) aim to uncover genotype-phenotype relationships through a two-stage procedure: predicting gene expression from genotypes using an expression quantitative trait locus (eQTL) data set, then testing the pred...
Humans Phenotype Transcriptome Genotype Deep Learning Models, Genetic Genome-Wide Association Study Gene Expression Polymorphism, Single Nucleotide Quantitative Trait Loci
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Valid inference for machine learning-assisted genome-wide association studies.

Nature genetics Sep 30, 2024
Machine learning (ML) has become increasingly popular in almost all scientific disciplines, including human genetics. Owing to challenges related to sample collection and precise phenotyping, ML-assisted genome-wide association study (GWAS), which us...
Phenotype Bone Density Genome-Wide Association Study Polymorphism, Single Nucleotide Humans Machine Learning Algorithms
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Machine Learning-Aided Ultra-Low-Density Single Nucleotide Polymorphism Panel Helps to Identify the Tharparkar Cattle Breed: Lessons for Digital Transformation in Livestock Genomics.

Omics : a journal of integrative biology Sep 20, 2024
Cattle breed identification is crucial for livestock research and sustainable food systems, and advances in genomics and artificial intelligence present new opportunities to address these challenges. This study investigates the identification of the ...
Machine Learning Animals Livestock Genome-Wide Association Study Cattle Genomics Polymorphism, Single Nucleotide Breeding
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