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Proportional Hazards Models

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CoxFNN: Interpretable machine learning method for survival analysis.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Survival analysis plays a pivotal role in healthcare, particularly in analyzing time-to-event data such as in disease progression, treatment efficacy, and drug development. Traditional methods in survival analysis often face a trade-off: they either ...

Prognostic Features for Overall Survival in Male Diabetic Patients Undergoing Hemodialysis Using Elastic Net Penalized Cox Regression; A Machine Learning Approach.

Archives of Iranian medicine
BACKGROUND: Diabetics constitute a significant percentage of hemodialysis (HD) patients with higher mortality, especially among male patients. A machine learning algorithm was used to optimize the prediction of time to death in male diabetic hemodial...

Development of a Machine Learning-Powered Optimized Lung Allocation System for Maximum Benefits in Lung Transplantation: A Korean National Data.

Journal of Korean medical science
BACKGROUND: An ideal lung allocation system should reduce waiting list deaths, improve transplant survival, and ensure equitable organ allocation. This study aimed to develop a novel lung allocation score (LAS) system, the MaxBenefit LAS, to maximize...

Development of PDAC diagnosis and prognosis evaluation models based on machine learning.

BMC cancer
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is difficult to detect early and highly aggressive, often leading to poor patient prognosis. Existing serum biomarkers like CA19-9 are limited in early diagnosis, failing to meet clinical needs. Mac...

Life's Crucial 9 and NAFLD from association to SHAP-interpreted machine learning predictions.

Scientific reports
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Cardiovascular disease (CVD) and NAFLD share multiple common risk factors. Life's Crucial 9 (LC9), a novel indicator for comprehensive assessment of card...

Research on Prediction model of Carotid-Femoral Pulse Wave Velocity: Based on Machine Learning Algorithm.

Journal of clinical hypertension (Greenwich, Conn.)
Carotid-femoral pulse wave velocity (cf-PWV) is an important but difficult to obtain measure of arterial stiffness and an independent predictor of cardiovascular events and all-cause mortality. The objective of this study was to develop a predictive ...

Guidelines and Best Practices for the Use of Targeted Maximum Likelihood and Machine Learning When Estimating Causal Effects of Exposures on Time-To-Event Outcomes.

Statistics in medicine
Targeted maximum likelihood estimation (TMLE) is an increasingly popular framework for the estimation of causal effects. It requires modeling both the exposure and outcome but is doubly robust in the sense that it is valid if at least one of these mo...

Cox-Sage: enhancing Cox proportional hazards model with interpretable graph neural networks for cancer prognosis.

Briefings in bioinformatics
High-throughput sequencing technologies have facilitated a deeper exploration of prognostic biomarkers. While many deep learning (DL) methods primarily focus on feature extraction or employ simplistic fully connected layers within prognostic modules,...

Factor enhanced DeepSurv: A deep learning approach for predicting survival probabilities in cirrhosis data.

Computers in biology and medicine
BACKGROUND: Over the years, various models, including both traditional and machine learning models, have been employed to predict survival probabilities for diverse survival datasets. The objective is to obtain models that provide more accurate estim...

MRI-Based Topology Deep Learning Model for Noninvasive Prediction of Microvascular Invasion and Assisting Prognostic Stratification in HCC.

Liver international : official journal of the International Association for the Study of the Liver
BACKGROUND & AIMS: Microvascular invasion (MVI) is associated with poor prognosis in hepatocellular carcinoma (HCC). Topology may improve the predictive performance and interpretability of deep learning (DL). We aimed to develop and externally valida...