AIMC Topic: Proportional Hazards Models

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Integrating machine learning and time-to-event models to explain and predict risk of hospitalization due to dengue in Colombia.

Scientific reports
Arboviral diseases such as dengue pose major public health challenges in endemic regions, notably in Norte de Santander (Colombia), where they place substantial pressure on healthcare services. We analyzed 8,814 confirmed dengue cases reported to the...

Assessing the accuracy of survival machine learning and traditional statistical models for Alzheimer's disease prediction over time: a study on the ADNI cohort.

BMC medical research methodology
BACKGROUND: Mild cognitive impairment (MCI) represents a transitional stage to Alzheimer's disease (AD), making progression prediction crucial for timely intervention. Predictive models integrating clinical, laboratory, and survival data can enhance ...

BRCAGenie: A machine learning-driven 43-gene polygenic risk score model for precision prediction of breast cancer survival.

Journal of translational medicine
BACKGROUND: Breast cancer is one of the most prevalent malignancies globally, imposing a substantial disease burden. Its inherent heterogeneity complicates prognosis and treatment, underscoring the need for accurate survival prediction models to guid...

The prognostic value of POD24 for multiple myeloma: a comprehensive analysis based on traditional statistics and machine learning.

BMC cancer
BACKGROUND: In multiple myeloma, progression within 24 months (POD24) is a strong adverse prognostic factor. However, its impact on overall survival (OS) remains underexplored through machine learning.

Enhancing explainability of random survival forests in predicting stent patency risk for malignant colonic obstruction.

BMC gastroenterology
BACKGROUND: This study aims to enhance the explainability and predictive accuracy of the Random Survival Forest (RSF) algorithm in predicting stent patency risk for patients with malignant colonic obstruction.

Computational pathology approach for assessment of prognosis and immunotherapy response in pan-gastrointestinal cancer.

Journal of translational medicine
BACKGROUND: Current cancer staging methods cannot accurately predict survival outcomes and therapeutic benefits in cancer patients. Digital pathomics, a rapidly evolving field, holds significant potential to revolutionize disease evaluation.

A prognostic model for gastric cancer constructed by multiple machine learning algorithms.

Journal of molecular histology
Gastric cancer (GC) is a highly heterogeneous disease that requires highly accurate prognostic models. Machine learning is a powerful tool for identifying predictive biomarkers and developing prognostic models. Here, we aim to integrate bioinformatic...

A novel potential biomarker panel to diagnose depression derived from big proteomic data.

Journal of affective disorders
BACKGROUND: There is still no clinical biomarker to diagnose depression. Given the complexity of a multifactorial disease like depression, a single biomarker is unlikely to capture the full heterogeneity of the disease and be applicable in clinical p...

Development and validation of a machine learning model integrating BUN/Cr ratio for mortality prediction in critically ill atrial fibrillation patients.

Scientific reports
Atrial fibrillation (AF), the most prevalent critical care arrhythmia, demonstrates substantial mortality associations where renal dysfunction management plays a pivotal therapeutic role. We examined the prognostic capacity of admission blood urea ni...

Invasive and non-invasive variables prediction models for cardiovascular disease-specific mortality between machine learning vs. traditional statistics.

Scientific reports
This study examined the predictive performance of cardiovascular disease (CVD)-specific mortality using traditional statistical and machine learning models with non-invasive indicators, and assessed whether adding blood lipid profiles improves predic...