AIMC Topic: Radiopharmaceuticals

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Novel molecular imaging approaches in oncology: towards a more accurate estimation of tumour response.

Current opinion in oncology
PURPOSE OF REVIEW: With novel therapeutics improving cancer survival rates, the need for accurate treatment response assessment has become increasingly crucial. The Response Evaluation Criteria in Solid Tumours remains the standard imaging method for...

A radiogenomics study on F-FDG PET/CT in endometrial cancer by a novel deep learning segmentation algorithm.

BMC cancer
OBJECTIVE: To create an automated PET/CT segmentation method and radiomics model to forecast Mismatch repair (MMR) and TP53 gene expression in endometrial cancer patients, and to examine the effect of gene expression variability on image texture feat...

Synthesizing [F]PSMA-1007 PET bone images from CT images with GAN for early detection of prostate cancer bone metastases: a pilot validation study.

BMC cancer
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...

Evaluation of amyloid PET positivity using machine learning on F-FDG PET images.

Japanese journal of radiology
BACKGROUND: Since the approval of disease-modifying drugs for Alzheimer's disease, the demand for amyloid positron emission tomography (PET) scans, which are crucial for determining treatment eligibility, is expected to increase significantly. We thu...

Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Single-time-point (STP) image-based dosimetry offers a more convenient approach for clinical practice in radiopharmaceutical therapy (RPT) compared with conventional multiple-time-point image-based dosimetry. Despite numerous advancements, current ST...

F-FDG PET/CT-based deep learning models and a clinical-metabolic nomogram for predicting high-grade patterns in lung adenocarcinoma.

BMC medical imaging
BACKGROUND: To develop and validate deep learning (DL) and traditional clinical-metabolic (CM) models based on 18 F-FDG PET/CT images for noninvasively predicting high-grade patterns (HGPs) of invasive lung adenocarcinoma (LUAD).

Prediction of PD-L1 expression in NSCLC patients using PET/CT radiomics and prognostic modelling for immunotherapy in PD-L1-positive NSCLC patients.

Clinical radiology
AIM: To develop a positron emission tomography/computed tomography (PET/CT)-based radiomics model for predicting programmed cell death ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) patients and estimating progression-free survival...

Machine learning models for enhanced diagnosis and risk assessment of prostate cancer with Ga-PSMA-617 PET/CT.

European journal of radiology
OBJECTIVE: Prostate cancer (PCa) is highly heterogeneous, making early detection of adverse pathological features crucial for improving patient outcomes. This study aims to predict PCa aggressiveness and identify radiomic and protein biomarkers assoc...

The value of radiomics and deep learning based on PET/CT in predicting perineural nerve invasion in rectal cancer.

Abdominal radiology (New York)
OBJECTIVE: The objective of this study is to investigate the value of radiomics features and deep learning features based on positron emission tomography/computed tomography (PET/CT) in predicting perineural invasion (PNI) in rectal cancer.