AIMC Topic: Rats
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Multitarget Natural Compounds for Ischemic Stroke Treatment: Integration of Deep Learning Prediction and Experimental Validation.
Journal of chemical information and modeling
Mar 14, 2025
Ischemic stroke's complex pathophysiology demands therapeutic approaches targeting multiple pathways simultaneously, yet current treatments remain limited. We developed an innovative drug discovery pipeline combining a deep learning approach with exp...
A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co-exposure.
Ecotoxicology and environmental safety
Mar 14, 2025
BACKGROUND: Within the past two decades, high-profile cases of melamine (MA) exposure have raised significant toxicological concerns, particularly regarding food adulteration. While widely used as a fundamental organic chemical intermediate in variou...
Of rats and robots: A mutual learning paradigm.
Journal of the experimental analysis of behavior
Mar 12, 2025
Robots are increasingly used alongside Skinner boxes to train animals in operant conditioning tasks. Similarly, animals are being employed in artificial intelligence research to train various algorithms. However, both types of experiments rely on uni...
Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments.
Frontiers in immunology
Mar 4, 2025
BACKGROUND: Acute kidney injury (AKI) after kidney transplantation is one of the main causes of graft loss and poor patient prognosis, and it is important to explore new targets for treating AKI in kidney transplantation.
A deep learning strategy to identify cell types across species from high-density extracellular recordings.
Cell
Feb 28, 2025
High-density probes allow electrophysiological recordings from many neurons simultaneously across entire brain circuits but fail to reveal cell type. Here, we develop a strategy to identify cell types from extracellular recordings in awake animals an...
Prediction and validation of anoikis-related genes in neuropathic pain using machine learning.
PloS one
Feb 27, 2025
BACKGROUND: Neuropathic pain (NP) can be induced by a variety of clinical conditions, such as spinal cord injury, lumbar disc herniation (LDH), lumbar spinal stenosis, diabetes, herpes zoster, and spinal cord tumors, and inflammatory stimuli. The pat...
Integrating manual preprocessing with automated feature extraction for improved rodent seizure classification.
Epilepsy & behavior : E&B
Feb 20, 2025
HYPOTHESIS/OBJECTIVE: Rodent models of epilepsy can help with the search for more effective drug candidates or neuromodulatory therapies. Yet, preclinical screening of candidate options for anti-epileptic drugs (AED) using rodent models may require h...
MARBLE: interpretable representations of neural population dynamics using geometric deep learning.
Nature methods
Feb 17, 2025
The dynamics of neuron populations commonly evolve on low-dimensional manifolds. Thus, we need methods that learn the dynamical processes over neural manifolds to infer interpretable and consistent latent representations. We introduce a representatio...
Robotic Fast Patch Clamp in Brain Slices Based on Stepwise Micropipette Navigation and Gigaseal Formation Control.
Sensors (Basel, Switzerland)
Feb 13, 2025
The patch clamp technique has become the gold standard for neuron electrophysiology research in brain science. Brain slices have been widely utilized as the targets of the patch clamp technique due to their higher optical transparency compared to a l...
Deciphering the role of cuproptosis in the development of intimal hyperplasia in rat carotid arteries using single cell analysis and machine learning techniques.
Scientific reports
Feb 12, 2025
UNLABELLED: This study aims to explore the regulatory role of cuproptosis in carotid intimal hyperplasia (IH), providing new insights into its pathophysiological mechanisms and potential diagnostic and therapeutic strategies.
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