AIMC Topic: Reactive Oxygen Species

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Data-driven machine learning modeling reveals the impact of micro/nanoplastics on microalgae and their key underlying mechanisms.

Journal of hazardous materials
Micro- and nano-plastics (MNPs) pose a growing threat to freshwater microalgae, leading to water quality and biodiversity. Traditional experiments often encounter difficulties in terms of cost, time, and capturing complex interactions when exploring ...

Engineered nanomaterials and macrophages: Toxicity mechanisms and protective strategies.

International immunopharmacology
Engineered nanomaterials (ENMs) have gained extensive applications across diverse fields, yet their potential cytotoxicity, particularly toward the immune system, raises significant safety concerns. As critical sentinels of innate immunity, macrophag...

An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is a major contributor to poor prognosis. Prunella vulgaris (P. vulgaris), a traditional medicinal herb, has shown potential in inhibiting PTC metastasis, but its molecular ...

Machine learning reveals genes impacting oxidative stress resistance across yeasts.

Nature communications
Reactive oxygen species (ROS) are highly reactive molecules encountered by yeasts during routine metabolism and during interactions with other organisms, including host infection. Here, we characterize the variation in resistance to the ROS-inducing ...

Photocatalytic microrobots for treating bacterial infections deep within sinuses.

Science robotics
Microrobotic techniques are promising for treating biofilm infections located deep within the human body. However, the presence of highly viscous pus presents a formidable biological barrier, severely restricting targeted and minimally invasive treat...

Protective effects of minocycline on dermal fibroblast cells from oxidant and apoptotic effects of HO: A comprehensive analysis with Raman spectroscopy and data-driven approach.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Minocycline (Mino) is an antibiotic with neuroprotective, anti-inflammatory, and antioxidant properties. This study investigated the protective effects of Mino against hydrogen peroxide (HO)-induced oxidative damage in dermal fibroblast cells and ana...

Eyes Are the Windows to the Soul: Reviewing the Possible Use of the Retina to Indicate Traumatic Brain Injury.

International journal of molecular sciences
Traumatic brain injury (TBI) induces complex molecular and cellular responses, often leading to vision deterioration and potential mortality. Current objective diagnostic methods are limited, necessitating the development of novel tools to assess dis...

Antifungal activity and mechanism of novel peptide antimicrobial peptide (GmAMP) against fluconazole-resistant .

PeerJ
BACKGROUND: There is a pressing need to create innovative alternative treatment approaches considering the overuse of antifungal drugs causes the number of clinically isolated fluconazole-resistant species to increase. antimicrobial peptide (GmAMP)...

Effect of PUFAs-ω3 and ω6 on oxidative stress of sheep erythrocytes.

BMC veterinary research
BACKGROUND: In recent years, the use of long-chain polyunsaturated fatty acids (PUFA) ω3 and ω6, as food supplements in livestock has increased due to their beneficial properties related to their antioxidant activity. It has been demonstrated however...

Mitochondrial dysfunction and cell death induced by Toona sinensis leaf extracts through MEK/ERK signaling in glioblastoma cells.

PloS one
Toona sinensis, a kind of phytochemicals in traditional Chinese medicine widely used in South-East Asia, has been recognized for its anticancer properties, particularly against various types of cancer. We aimed to evaluate the effectiveness of T. sin...