RATIONALE AND OBJECTIVES: To differentiate early-onset schizophrenia (EOS) from early-onset bipolar disorder (EBD) using surface-based morphometry measurements and brain volumes using machine learning (ML) algorithms.
The response variability to repetitive transcranial magnetic stimulation (rTMS) challenges the effective use of this treatment option in patients with schizophrenia. This variability may be deciphered by leveraging predictive information in structura...
Physical and engineering sciences in medicine
Apr 23, 2024
Schizophrenia (SZ) has been acknowledged as a highly intricate mental disorder for a long time. In fact, individuals with SZ experience a blurred line between fantasy and reality, leading to a lack of awareness about their condition, which can pose s...
Schizophrenia is a profound and enduring mental disorder that imposes significant negative impacts on individuals, their families, and society at large. The development of more accurate and objective diagnostic tools for schizophrenia can be expedite...
Computer methods in biomechanics and biomedical engineering
Feb 20, 2024
Drug discovery relies on the precise prognosis of drug-target interactions (DTI). Due to their ability to learn from raw data, deep learning (DL) methods have displayed outstanding performance over traditional approaches. However, challenges such as ...
As interpersonal synchrony plays a key role in building rapport, the perception of another agent's synchronizing behavior could be an important feature to assess, especially with patients with social deficits such as in schizophrenia. Twenty-four sch...
It is widely hoped that statistical models can improve decision-making related to medical treatments. Because of the cost and scarcity of medical outcomes data, this hope is typically based on investigators observing a model's success in one or two d...
UNLABELLED: Disorders of systemic immunity and immune processes in the brain have now been shown to play an essential role in the development and progression of schizophrenia. Nevertheless, only a few works were devoted to the study of some immune pa...
BACKGROUND: Mood disorders and schizophrenia affect millions worldwide. Currently, diagnosis is primarily determined by reported symptomatology. As symptoms may overlap, misdiagnosis is common, potentially leading to ineffective or destabilizing trea...
European archives of psychiatry and clinical neuroscience
Oct 25, 2023
Blunted affect is associated with severe mental illness, particularly schizophrenia. Mechanisms of blunted affect are poorly understood, potentially due to a lack of phenomenological clarity. Here, we examine clinician rated blunted affect and comput...