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Sepsis

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Transfer learning-enabled outcome prediction for guiding CRRT treatment of the pediatric patients with sepsis.

BMC medical informatics and decision making
Continuous renal replacement therapy (CRRT) is a life-saving procedure for sepsis but the benefit of CRRT varies and prediction of clinical outcomes is valuable in efficient treatment planning. This study aimed to use machine learning (ML) models tra...

Unveiling the glycolysis in sepsis: Integrated bioinformatics and machine learning analysis identifies crucial roles for IER3, DSC2, and PPARG in disease pathogenesis.

Medicine
Sepsis, a multifaceted syndrome driven by an imbalanced host response to infection, remains a significant medical challenge. At its core lies the pivotal role of glycolysis, orchestrating immune responses especially in severe sepsis. The intertwined ...

Machine learning reveals the rules governing the efficacy of mesenchymal stromal cells in septic preclinical models.

Stem cell research & therapy
BACKGROUND: Mesenchymal Stromal Cells (MSCs) are the preferred candidates for therapeutics as they possess multi-directional differentiation potential, exhibit potent immunomodulatory activity, are anti-inflammatory, and can function like antimicrobi...

Machine learning-based prognostic model for 30-day mortality prediction in Sepsis-3.

BMC medical informatics and decision making
BACKGROUND: Sepsis poses a critical threat to hospitalized patients, particularly those in the Intensive Care Unit (ICU). Rapid identification of Sepsis is crucial for improving survival rates. Machine learning techniques offer advantages over tradit...

Predicting Mortality in Sepsis-Associated Acute Respiratory Distress Syndrome: A Machine Learning Approach Using the MIMIC-III Database.

Journal of intensive care medicine
BackgroundTo develop and validate a mortality prediction model for patients with sepsis-associated Acute Respiratory Distress Syndrome (ARDS).MethodsThis retrospective cohort study included 2466 patients diagnosed with sepsis and ARDS within 24 h of ...

Essential blood molecular signature for progression of sepsis-induced acute lung injury: Integrated bioinformatic, single-cell RNA Seq and machine learning analysis.

International journal of biological macromolecules
In this study, we aimed to identify an essential blood molecular signature for chacterizing the progression of sepsis-induced acute lung injury using integrated bioinformatic and machine learning analysis. The results showed that a total of 88 functi...

FedDSS: A data-similarity approach for client selection in horizontal federated learning.

International journal of medical informatics
BACKGROUND AND OBJECTIVE: Federated learning (FL) is an emerging distributed learning framework allowing multiple clients (hospitals, institutions, smart devices, etc.) to collaboratively train a centralized machine learning model without disclosing ...

Machine learning interpretability methods to characterize the importance of hematologic biomarkers in prognosticating patients with suspected infection.

Computers in biology and medicine
OBJECTIVE: To evaluate the effectiveness of Monocyte Distribution Width (MDW) in predicting sepsis outcomes in emergency department (ED) patients compared to other hematologic parameters and vital signs, and to determine whether routine parameters co...

Development and validation of a sepsis risk index supporting early identification of ICU-acquired sepsis: an observational study.

Anaesthesia, critical care & pain medicine
BACKGROUND: Sepsis is a threat to global health, and domestically is the major cause of in-hospital mortality. Due to increases in inpatient morbidity and mortality resulting from sepsis, healthcare providers (HCPs) would accrue significant benefits ...