OBJECTIVE: Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of inflammation and neurological involvement in the pathophysiology of preeclampsia, this study aimed ...
BACKGROUND: Myxomatous mitral valve disease (MMVD) represents the most prevalent cardiac disorder in dogs, frequently resulting in mitral regurgitation (MR) and congestive heart failure. Although echocardiography is the gold standard for diagnosis, i...
Frontiers in cellular and infection microbiology
May 2, 2025
INTRODUCTION: HIV-associated cryptococcosis is marked by unpredictable disease trajectories and persistently high mortality rates worldwide. Although improved risk stratification and tailored clinical management are urgently needed to enhance patient...
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Apr 29, 2025
BACKGROUND: Effective chronic pancreatitis (CP) treatment requires accurate severity evaluation, but no histopathology grading system exists. This study aimed to develop and validate a novel CP pathological grade (Histopathology-derived CPpG) using q...
Prediction of severe disease (SVD) in patients with coronavirus disease (COVID-19) pneumonia at an early stage could allow for more appropriate triage and improve patient prognosis. Moreover, the visualization of the topological properties of COVID-1...
Aortic stenosis (AS) is a prevalent heart valve disease that requires accurate and timely diagnosis for effective treatment. Current methods for automated AS severity classification rely on black-box deep learning techniques, which suffer from a low ...
The international journal of cardiovascular imaging
Apr 22, 2025
In symptomatic patients undergoing coronary CTA for suspected coronary artery disease (CAD), we assessed if quantification of plaque burden, in addition to luminal narrowing and clinical risk factors, offers incremental value for the identification o...
This study aimed to explore potential risk factors for severe endometriosis and to develop a model to predict the risk of severe endometriosis. A total of 308 patients with endometriosis were analyzed. Least absolute shrinkage and selection operator ...
BACKGROUND: The Neurostatus-Expanded Disability Status Scale (EDSS) is the most frequently used measure of disability in multiple sclerosis (MS) trials. However, EDSS scores ⩾4.5 are mainly based on ambulation and may fail to capture relevant disabil...
BMC medical informatics and decision making
Apr 18, 2025
This study aimed to identify key predictors for the severity of High Altitude Pulmonary Edema (HAPE) to assist clinicians in promptly recognizing severely affected patients in the emergency department, thereby reducing associated mortality rates. Mul...
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