AIMC Topic: Signal Transduction
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Toll-like receptor signaling in vertebrates: testing the integration of protein, complex, and pathway data in the protein ontology framework.
PloS one
Apr 20, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation o...
The potential of AOP networks for reproductive and developmental toxicity assay development.
Reproductive toxicology (Elmsford, N.Y.)
Apr 15, 2015
Historically, the prediction of reproductive and developmental toxicity has largely relied on the use of animals. The adverse outcome pathway (AOP) framework forms a basis for the development of new non-animal test methods. It also provides biologica...
Gene Expression Regulation, Developmental
Humans
Models, Biological
Computer Simulation
Toxicity Tests
Knowledge Bases
Animals
Pregnancy
Reproduction
Animal Testing Alternatives
Risk Assessment
Female
Embryonic Development
Systems Integration
Gene Regulatory Networks
Fetal Development
Signal Transduction
Functional annotation and biological interpretation of proteomics data.
Biochimica et biophysica acta
Oct 31, 2014
Proteomics experiments often generate a vast amount of data. However, the simple identification and quantification of proteins from a cell proteome or subproteome is not sufficient for the full understanding of complex mechanisms occurring in the bio...
Inter-species pathway perturbation prediction via data-driven detection of functional homology.
Bioinformatics (Oxford, England)
Aug 22, 2014
MOTIVATION: Experiments in animal models are often conducted to infer how humans will respond to stimuli by assuming that the same biological pathways will be affected in both organisms. The limitations of this assumption were tested in the IMPROVER ...
Phosphoproteins
Gene Expression Regulation
Models, Animal
Species Specificity
Oligonucleotide Array Sequence Analysis
Bronchi
Signal Transduction
Epithelial Cells
Phosphorylation
Translational Research, Biomedical
Gene Expression Profiling
Systems Biology
Rats
Cells, Cultured
Cytokines
Humans
Databases, Factual
Artificial Intelligence
Animals
Software
Algorithms
Traditional Chinese Medicine for Anti-Arrhythmias: Mechanisms via Potassium Channels.
Basic & clinical pharmacology & toxicology
Jul 1, 2025
Cardiac arrhythmia is a common life-threatening cardiovascular disorder. Potassium channels play a crucial role in cardiac electrophysiology, and their dysfunction is closely associated with the occurrence and development of arrhythmia. Traditional C...
Computer-aided unveiling molecular mechanisms of Xylocarpus granatum against colorectal cancer: therapeutic intervention targeting P13K-AKT signaling pathway.
Computers in biology and medicine
Jul 1, 2025
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality globally, with increasing incidence rates, particularly in early-onset cases. Despite advances in treatment, many developing countries face affordability and safety ...
Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1/TTK signaling pathway and structural insights in the NCI-60.
Computers in biology and medicine
Jul 1, 2025
Ovarian cancer remains the third most prevalent and deadliest gynecologic malignancy worldwide, with most patients eventually developing resistance to platinum-based chemotherapy. This highlights a critical unmet need for innovative multitargeted the...
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions.
Ageing research reviews
Jul 1, 2025
Synaptic plasticity is a neuron's intrinsic ability to make new connections throughout life. The morphology and function of synapses are highly susceptible to any pathological condition. Ischemic stroke is a cerebrovascular event that affects various...
Sepsis Important Genes Identification Through Biologically Informed Deep Learning and Transcriptomic Analysis.
Clinical and experimental pharmacology & physiology
Jul 1, 2025
Sepsis is a life-threatening disease caused by the dysregulation of the immune response. It is important to identify influential genes modulating the immune response in sepsis. In this study, we used P-NET, a biologically informed explainable artific...
Exploration of Active Substances and Its Potential Mechanism of Gancao Fuzi Decoction on Inflammatory Based on Metabolomics and Network Pharmacology.
Rapid communications in mass spectrometry : RCM
May 30, 2025
Gancao Fuzi decoction (GCFZT) is a traditional Chinese formula, which has been commonly used in clinical practice to treat inflammatory diseases. However, the active substance of GCFZT in the treatment of inflammation is not fully clarified. In this ...
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