AIMC Topic: Signal Transduction

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The transfer and transformation of collective network information in gene-matched networks.

Scientific reports Oct 9, 2015
Networks, such as the human society network, social and professional networks, and biological system networks, contain vast amounts of information. Information signals in networks are distributed over nodes and transmitted through intricately wired l...
Humans Neural Networks, Computer Neurons Nerve Net Signal Transduction Algorithms Models, Neurological Gene Regulatory Networks Models, Genetic
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PathwaysWeb: a gene pathways API with directional interactions, expanded gene ontology, and versioning.

Bioinformatics (Oxford, England) Sep 23, 2015
UNLABELLED: PathwaysWeb is a resource-based, well-documented web system that provides publicly available information on genes, biological pathways, Gene Ontology (GO) terms, gene-gene interaction networks (importantly, with the directionality of inte...
Information Storage and Retrieval Gene Ontology Computational Biology Humans Signal Transduction Algorithms Internet Databases, Factual Gene Regulatory Networks Mice Animals Protein Interaction Maps
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Machine Learning-based Classification of Diffuse Large B-cell Lymphoma Patients by Their Protein Expression Profiles.

Molecular & cellular proteomics : MCP Aug 26, 2015
Characterization of tumors at the molecular level has improved our knowledge of cancer causation and progression. Proteomic analysis of their signaling pathways promises to enhance our understanding of cancer aberrations at the functional level, but ...
Proteomics Phosphoprotein Phosphatases Proteome Tissue Embedding Neoplasm Proteins Humans Principal Component Analysis Machine Learning Cell Line, Tumor Gene Expression Regulation, Neoplastic Biomarkers, Tumor Lymphoma, Large B-Cell, Diffuse Formaldehyde Apoptosis Regulatory Proteins Isotope Labeling GTPase-Activating Proteins Neprilysin Signal Transduction Tissue Fixation
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Network fingerprint: a knowledge-based characterization of biomedical networks.

Scientific reports Aug 26, 2015
It can be difficult for biomedical researchers to understand complex molecular networks due to their unfamiliarity with the mathematical concepts employed. To represent molecular networks with clear meanings and familiar forms for biomedical research...
Knowledge Bases Pattern Recognition, Automated Protein Interaction Mapping Humans Algorithms Computer Simulation Signal Transduction Models, Biological Animals Proteome
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Classification of signaling proteins based on molecular star graph descriptors using Machine Learning models.

Journal of theoretical biology Aug 20, 2015
Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein structure hinders...
Humans Machine Learning Signal Transduction Databases, Protein Quantitative Structure-Activity Relationship Intracellular Signaling Peptides and Proteins
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Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.

PLoS computational biology Aug 7, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events. In a typical phosphoproteomics study, phos...
Proteomics Proteome Signal Transduction Cell Line Humans Cell Communication Knowledge Bases Embryonic Stem Cells Databases, Protein Cell Differentiation Phosphoproteins
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Prediction of MicroRNA-Disease Associations Based on Social Network Analysis Methods.

BioMed research international Jul 26, 2015
MicroRNAs constitute an important class of noncoding, single-stranded, ~22 nucleotide long RNA molecules encoded by endogenous genes. They play an important role in regulating gene transcription and the regulation of normal development. MicroRNAs can...
MicroRNAs Humans Genetic Predisposition to Disease Pattern Recognition, Automated Machine Learning Models, Genetic Social Networking Signal Transduction Algorithms Databases, Genetic Computer Simulation
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Installing a Local Copy of the Reactome Web Site and Knowledgebase.

Current protocols in bioinformatics Jun 19, 2015
The Reactome project builds, maintains, and publishes a knowledgebase of biological pathways. The information in the knowledgebase is gathered from the experts in the field, peer reviewed and edited by Reactome editorial staff, and then published to ...
Knowledge Bases Databases as Topic Software Signal Transduction Internet
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TENET: topological feature-based target characterization in signalling networks.

Bioinformatics (Oxford, England) Jun 16, 2015
MOTIVATION: Target characterization for a biochemical network is a heuristic evaluation process that produces a characterization model that may aid in predicting the suitability of each molecule for drug targeting. These approaches are typically used...
Humans Signal Transduction Support Vector Machine Software Algorithms Protein Interaction Mapping
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Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Environmental toxicology May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Cell Migration Assays, Macrophage Middle Aged Chemotaxis, Leukocyte Estradiol Diethylhexyl Phthalate Inflammation Interleukin-1beta Macrophages NF-kappa B Lipopolysaccharides Signal Transduction Humans Cytokines Benzhydryl Compounds Cell Movement Phenols Tumor Necrosis Factor-alpha Female Cells, Cultured
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