Laser desorption-ionization mass spectrometry (LDI-MS) is prized for its rapidity, simplicity, low sample consumption, and high throughput in metabolic analysis, with great potential as a diagnostic tool. Herein, an LDI-MS method with sulfone-contain...
Journal of chemical theory and computation
Sep 2, 2025
Sodium-proton antiporter NhaA of is a paradigm to investigate the mechanistic basis of the fundamental Na/H exchange in cells. However, all existing crystal structures of NhaA are inward-facing (IF), and the putative outward-facing (OF) structures a...
PURPOSE: Sodium neuroimaging provides unique insights into the cellular and metabolic properties of brain tumors. However, at 3T, sodium neuroimaging MRI's low signal-to-noise ratio (SNR) and resolution discourages routine clinical use. We evaluated ...
Sodium transporters maintain cellular homeostasis by transporting ions, minerals, and nutrients across the membrane, and Na+/K+ ATPases facilitate the cotransport of solutes in neurons, muscle cells, and epithelial cells. Sodium transporters are impo...
With the recent surge in the development of highly selective probes, fluorescence microscopy has become one of the most widely used approaches to studying cellular properties and signaling in living cells and tissues. Traditionally, microscopy image ...
Soil salinization is a critical global issue for sustainable agriculture, impacting crop yields and posing a threat to achieving the Sustainable Development Goal (SDG) of ensuring food security. It is necessary to monitor it in detail and uncover its...
High-affinity ligand peptides for ion channels are essential for controlling the flow of ions across the plasma membrane. These peptides are now being investigated as possible therapeutic possibilities for a variety of illnesses, including cancer and...
Journal of the American Heart Association
May 10, 2024
BACKGROUND: Accurate quantification of sodium intake based on self-reported dietary assessments has been a persistent challenge. We aimed to apply machine-learning (ML) algorithms to predict 24-hour urinary sodium excretion from self-reported questio...
IEEE journal of biomedical and health informatics
May 6, 2024
Survival analysis is employed to analyze the time before the event of interest occurs, which is broadly applied in many fields. The existence of censored data with incomplete supervision information about survival outcomes is one key challenge in sur...
PURPOSE: Na MRI can be used to quantify in-vivo tissue sodium concentration (TSC), but the inherently low Na signal leads to long scan times and/or noisy or low-resolution images. Reconstruction algorithms such as compressed sensing (CS) have been pr...
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