Visible particle identification is a crucial prerequisite step for process improvement and control during the manufacturing of injectable biotherapeutic drug products. Raman spectroscopy is a technology with several advantages for particle identifica...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jun 25, 2022
Raman spectroscopy is a spectroscopic technique typically used to determine vibrational modes of molecules and is commonly used in chemistry to provide a structural fingerprint by which molecules can be identified. With the help of deep learning, Ram...
Raman spectroscopy is a powerful method for estimating the molecular structure of a target that can be adapted for biomedical analysis given its non-destructive nature. Inflammatory skin diseases impair the skin's barrier function and interfere with ...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jun 9, 2022
Aqueous extraction is the most common and cost-effective means of obtaining active ingredients from medicinal plants. However, botanical extracts generally contain high pigment content and complex chemical composition posing a challenge for the proce...
Nucleated red blood cells (NRBCs) as a type of rare cell present in an adult's peripheral blood is a concern in hematology, intensive care medicine and prenatal diagnostics. However, it is labor-intensive to screen such rare cells from real complex c...
The impact of the environment on the properties of graphene such as strain, charge density, and dielectric environment can be evaluated by Raman spectroscopy. These environmental interactions are not trivial to determine since they affect the spectra...
This paper proposes a rapid, label-free, and non-invasive approach for identifying murine cancer cells (B16F10 melanoma cancer cells) from non-cancer cells (C2C12 muscle cells) using machine-learning-assisted Raman spectroscopic imaging. Through quic...
Surface-enhanced Raman spectroscopy (SERS) has been recognized as a promising analytical technique for its capability of providing molecular fingerprint information and avoiding interference of water. Nevertheless, direct SERS detection of complicate...
Raman spectroscopy is a non-destructive analysis technique that provides detailed information about the chemical structure of tumors. Raman spectra of 52 giant cell tumors of bone (GCTB) and 21 adjacent normal tissues of formalin-fixed paraffin embed...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Mar 26, 2022
In this study, convolutional neural network based on Gramian angular field (GAF-CNN) was firstly proposed. The 1-D Raman spectral data was converted into images and used for predicting the biochemical value of blood glucose. 106 sets of blood spectru...
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