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Supervised Machine Learning

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Imputation of label-free quantitative mass spectrometry-based proteomics data using self-supervised deep learning.

Nature communications
Imputation techniques provide means to replace missing measurements with a value and are used in almost all downstream analysis of mass spectrometry (MS) based proteomics data using label-free quantification (LFQ). Here we demonstrate how collaborati...

Molecular Classification of Breast Cancer Using Weakly Supervised Learning.

Cancer research and treatment
PURPOSE: The molecular classification of breast cancer is crucial for effective treatment. The emergence of digital pathology has ushered in a new era in which weakly supervised learning leveraging whole-slide images has gained prominence in developi...

Analysis of factors that indicated surgery in 400 patients submitted to a complete diagnostic workup for obstructed defecation syndrome and rectal prolapse using a supervised machine learning algorithm.

Techniques in coloproctology
BACKGROUND: Patient selection is extremely important in obstructed defecation syndrome (ODS) and rectal prolapse (RP) surgery. This study assessed factors that guided the indications for ODS and RP surgery and their specific role in our decision-maki...

Three autism subtypes based on single-subject gray matter network revealed by semi-supervised machine learning.

Autism research : official journal of the International Society for Autism Research
Autism spectrum disorder (ASD) is a heterogeneous, early-onset neurodevelopmental condition characterized by persistent impairments in social interaction and communication. This study aims to delineate ASD subtypes based on individual gray matter bra...

Self-Supervised Learning Improves Accuracy and Data Efficiency for IMU-Based Ground Reaction Force Estimation.

IEEE transactions on bio-medical engineering
OBJECTIVE: Recent deep learning techniques hold promise to enable IMU-driven kinetic assessment; however, they require large extents of ground reaction force (GRF) data to serve as labels for supervised model training. We thus propose using existing ...

Leveraging permutation testing to assess confidence in positive-unlabeled learning applied to high-dimensional biological datasets.

BMC bioinformatics
BACKGROUND: Compared to traditional supervised machine learning approaches employing fully labeled samples, positive-unlabeled (PU) learning techniques aim to classify "unlabeled" samples based on a smaller proportion of known positive examples. This...

Driving Cognitive Alertness Detecting Using Evoked Multimodal Physiological Signals Based on Uncertain Self-Supervised Learning.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Multimodal physiological signals play a pivotal role in drivers' perception of work stress. However, the scarcity of labels and the multitude of modalities render the utilization of physiological signals for driving cognitive alertness detection chal...

URCA: Uncertainty-based region clipping algorithm for semi-supervised medical image segmentation.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Training convolutional neural networks based on large amount of labeled data has made great progress in the field of image segmentation. However, in medical image segmentation tasks, annotating the data is expensive and time...

Mapping the landscape of histomorphological cancer phenotypes using self-supervised learning on unannotated pathology slides.

Nature communications
Cancer diagnosis and management depend upon the extraction of complex information from microscopy images by pathologists, which requires time-consuming expert interpretation prone to human bias. Supervised deep learning approaches have proven powerfu...

Attention decoupled contrastive learning for semi-supervised segmentation method based on data augmentation.

Physics in medicine and biology
Deep learning algorithms have demonstrated impressive performance by leveraging large labeled data. However, acquiring pixel-level annotations for medical image analysis, especially in segmentation tasks, is both costly and time-consuming, posing cha...