AIMC Topic: Translational Research, Biomedical
Clear Filters Showing 21 to 30 of 94 articles
Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms.
Frontiers in immunology
Sep 7, 2021
RNA vaccines represent a milestone in the history of vaccinology. They provide several advantages over more traditional approaches to vaccine development, showing strong immunogenicity and an overall favorable safety profile. While preclinical testin...
Foundational Considerations for Artificial Intelligence Using Ophthalmic Images.
Ophthalmology
Aug 31, 2021
IMPORTANCE: The development of artificial intelligence (AI) and other machine diagnostic systems, also known as software as a medical device, and its recent introduction into clinical practice requires a deeply rooted foundation in bioethics for cons...
Translational precision medicine: an industry perspective.
Journal of translational medicine
Jun 5, 2021
In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of how drug...
Classification Criteria for Multiple Sclerosis-Associated Intermediate Uveitis.
American journal of ophthalmology
May 11, 2021
PURPOSE: The purpose of this study was to determine classification criteria for multiple sclerosis-associated intermediate uveitis.
5335 days of Implementation Science: using natural language processing to examine publication trends and topics.
Implementation science : IS
Apr 26, 2021
INTRODUCTION: Moving evidence-based practices into the hands of practitioners requires the synthesis and translation of research literature. However, the growing pace of scientific publications across disciplines makes it increasingly difficult to st...
Classification Criteria for Spondyloarthritis/HLA-B27-Associated Anterior Uveitis.
American journal of ophthalmology
Apr 15, 2021
PURPOSE: The purpose of this study was to determine classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis DESIGN: Machine learning of cases with spondyloarthritis/HLA-B27-associated anterior uveitis and 8 other anterior uv...
Driving success in personalized medicine through AI-enabled computational modeling.
Drug discovery today
Feb 17, 2021
The development of successful drugs is expensive and time-consuming because of high clinical attrition rates. This is caused partially by the rupture seen in the translatability of the drug from the bench to the clinic in the context of personalized ...
Use of Machine Learning to Re-Assess Patterns of Multivariate Functional Recovery after Fluid Percussion Injury: Operation Brain Trauma Therapy.
Journal of neurotrauma
Jan 13, 2021
Traumatic brain injury (TBI) is a leading cause of death and disability. Yet, despite immense research efforts, treatment options remain elusive. Translational failures in TBI are often attributed to the heterogeneity of the TBI population and limite...
Flow driven robotic navigation of microengineered endovascular probes.
Nature communications
Dec 22, 2020
Minimally invasive medical procedures, such as endovascular catheterization, have considerably reduced procedure time and associated complications. However, many regions inside the body, such as in the brain vasculature, still remain inaccessible due...
An integrative knowledge graph for rare diseases, derived from the Genetic and Rare Diseases Information Center (GARD).
Journal of biomedical semantics
Nov 12, 2020
BACKGROUND: The Genetic and Rare Diseases (GARD) Information Center was established by the National Institutes of Health (NIH) to provide freely accessible consumer health information on over 6500 genetic and rare diseases. As the cumulative scientif...
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