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Unsupervised Machine Learning

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GAN-based synthetic FDG PET images from T1 brain MRI can serve to improve performance of deep unsupervised anomaly detection models.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Research in the cross-modal medical image translation domain has been very productive over the past few years in tackling the scarce availability of large curated multi-modality datasets with the promising performance of GAN...

Unsupervised Deep Learning of Electronic Health Records to Characterize Heterogeneity Across Alzheimer Disease and Related Dementias: Cross-Sectional Study.

JMIR aging
BACKGROUND: Alzheimer disease and related dementias (ADRD) exhibit prominent heterogeneity. Identifying clinically meaningful ADRD subtypes is essential for tailoring treatments to specific patient phenotypes.

Anomaly Detection in Retinal OCT Images With Deep Learning-Based Knowledge Distillation.

Translational vision science & technology
PURPOSE: The purpose of this study was to develop a robust and general purpose artificial intelligence (AI) system that allows the identification of retinal optical coherence tomography (OCT) volumes with pathomorphological manifestations not present...

Uncovering hidden subtypes in dementia: An unsupervised machine learning approach to dementia diagnosis and personalization of care.

Journal of biomedical informatics
OBJECTIVE: Dementia represents a growing public health challenge, affecting an increasing number of individuals. It encompasses a broad spectrum of cognitive impairments, ranging from mild to severe stages, each of which demands varying levels of car...

Unsupervised Machine Learning-Based Image Recognition of Raw Infrared Spectra: Toward Chemist-like Chemical Structural Classification and Beyond Numerical Data.

Journal of chemical information and modeling
Recent advances in artificial intelligence have significantly improved spectral data analysis. In this study, we used unsupervised machine learning to classify chemical compounds based on infrared (IR) spectral images, without relying on prior chemic...

Unsupervised Learning of Progress Coordinates during Weighted Ensemble Simulations: Application to NTL9 Protein Folding.

Journal of chemical theory and computation
A major challenge for many rare-event sampling strategies is the identification of progress coordinates that capture the slowest relevant motions. Machine-learning methods that can identify progress coordinates in an unsupervised manner have therefor...

Unsupervised learning to identify symptom clusters in older adults undergoing chemotherapy.

Journal of geriatric oncology
INTRODUCTION: Unsupervised machine learning (ML) approaches such as clustering have not been commonly applied to patient-reported data. This study describes ML methods to explore and describe patient-reported symptom trajectories in older adults rece...

Definition of the microbial rare biosphere through unsupervised machine learning.

Communications biology
The microbial rare biosphere, composed of low-abundance microorganisms in a community, lacks a standardized delineation method for its definition. Currently, most studies rely on arbitrary thresholds to define the microbial rare biosphere (e.g., 0.1%...

Unsupervised Test-Time Adaptation for Hepatic Steatosis Grading Using Ultrasound B-Mode Images.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Ultrasound (US) is considered a key modality for the clinical assessment of hepatic steatosis (i.e., fatty liver) due to its noninvasiveness and availability. Deep learning methods have attracted considerable interest in this field, as they are capab...