AIMC Topic: Vascular Endothelial Growth Factor A

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Machine Learning Can Predict Anti-VEGF Treatment Demand in a Treat-and-Extend Regimen for Patients with Neovascular AMD, DME, and RVO Associated Macular Edema.

Ophthalmology. Retina May 8, 2021
PURPOSE: To assess the potential of machine learning to predict low and high treatment demand in real life in patients with neovascular age-related macular degeneration (nAMD), retinal vein occlusion (RVO), and diabetic macular edema (DME) treated ac...
Prognosis Retrospective Studies Female Aged Aged, 80 and over Humans Diabetic Retinopathy Machine Learning Vascular Endothelial Growth Factor A Intravitreal Injections Ranibizumab Wet Macular Degeneration Retinal Vein Occlusion Male Middle Aged Angiogenesis Inhibitors Follow-Up Studies Macular Edema
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AI-based structure-function correlation in age-related macular degeneration.

Eye (London, England) Mar 25, 2021
Sensitive and robust outcome measures of retinal function are pivotal for clinical trials in age-related macular degeneration (AMD). A recent development is the implementation of artificial intelligence (AI) to infer results of psychophysical examina...
Wet Macular Degeneration Humans Artificial Intelligence Angiogenesis Inhibitors Visual Acuity Tomography, Optical Coherence Vascular Endothelial Growth Factor A
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Predicting Incremental and Future Visual Change in Neovascular Age-Related Macular Degeneration Using Deep Learning.

Ophthalmology. Retina Jan 28, 2021
PURPOSE: To evaluate the predictive usefulness of quantitative imaging biomarkers, acquired automatically from OCT scans, of cross-sectional and future visual outcomes of patients with neovascular age-related macular degeneration (AMD) starting anti-...
Intravitreal Injections Ranibizumab Wet Macular Degeneration Follow-Up Studies Visual Acuity Tomography, Optical Coherence Vascular Endothelial Growth Factor A Retrospective Studies Female Aged Aged, 80 and over Cross-Sectional Studies Male Middle Aged Deep Learning Angiogenesis Inhibitors Humans Prognosis
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Quantification of Key Retinal Features in Early and Late Age-Related Macular Degeneration Using Deep Learning.

American journal of ophthalmology Jan 8, 2021
PURPOSE: We sought to develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD).
Humans Neural Networks, Computer Male Middle Aged Deep Learning ROC Curve Angiogenesis Inhibitors Female Aged Aged, 80 and over Sensitivity and Specificity Retinal Drusen Choroidal Neovascularization Geographic Atrophy Intravitreal Injections Recombinant Fusion Proteins Models, Statistical Ranibizumab Visual Acuity Wet Macular Degeneration Tomography, Optical Coherence Receptors, Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor A
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Porphyrin-based covalent organic framework as bioplatfrom for detection of vascular endothelial growth factor 165 through fluorescence resonance energy transfer.

Talanta Dec 30, 2020
A fluorescent aptasensor based on porphyrin-based covalent organic framework (p-COF) and carbon dots (CDs) was constructed for detecting vascular endothelial growth factor 165 (VEGF) and for imaging of the breast cancer cell line Michigan cancer foun...
Humans Limit of Detection Aptamers, Nucleotide Metal-Organic Frameworks Porphyrins Biosensing Techniques Vascular Endothelial Growth Factor A Quantum Dots Fluorescence Resonance Energy Transfer
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Predicting antibody affinity changes upon mutations by combining multiple predictors.

Scientific reports Nov 11, 2020
Antibodies are proteins working in our immune system with high affinity and specificity for target antigens, making them excellent tools for both biotherapeutic and bioengineering applications. The prediction of antibody affinity changes upon mutatio...
Vascular Endothelial Growth Factor A Databases as Topic Antibody Affinity Machine Learning Computational Biology Mutation Antibodies
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Prediction of response to anti-vascular endothelial growth factor treatment in diabetic macular oedema using an optical coherence tomography-based machine learning method.

Acta ophthalmologica Jun 22, 2020
PURPOSE: To predict the anti-vascular endothelial growth factor (VEGF) therapeutic response of diabetic macular oedema (DME) patients from optical coherence tomography (OCT) at the initiation stage of treatment using a machine learning-based self-exp...
Male Middle Aged ROC Curve Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Algorithms Tomography, Optical Coherence Humans Prognosis Macular Edema Diabetic Retinopathy Retrospective Studies Machine Learning Vascular Endothelial Growth Factor A Female Intravitreal Injections Aged
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A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study.

PloS one Apr 30, 2020
BACKGROUND AND OBJECTIVE: To develop a semi-automated, machine-learning based workflow to evaluate the ellipsoid zone (EZ) assessed by spectral domain optical coherence tomography (SD-OCT) in eyes with macular edema secondary to central retinal or he...
Tomography, Optical Coherence Drug Monitoring Workflow Macular Edema Humans Vascular Endothelial Growth Factor A Middle Aged Retinal Vein Occlusion Recombinant Fusion Proteins Pilot Projects Macula Lutea Machine Learning Image Processing, Computer-Assisted Receptors, Vascular Endothelial Growth Factor Female Angiogenesis Inhibitors Bevacizumab Adult Treatment Outcome Male
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Prediction of visual outcomes by an artificial neural network following intravitreal injection and laser therapy for retinopathy of prematurity.

The British journal of ophthalmology Nov 19, 2019
AIMS: To construct a program to predict the visual acuity (VA), best corrected VA (BCVA) and spherical equivalent (SE) of patients with retinopathy of prematurity (ROP) from 3 to 12 years old after intravitreal injection (IVI) of anti-vascular endoth...
Male Refraction, Ocular Child, Preschool Child Humans Ranibizumab Angiogenesis Inhibitors Neural Networks, Computer Visual Acuity Retinopathy of Prematurity Retrospective Studies Predictive Value of Tests Bevacizumab Female Vascular Endothelial Growth Factor A Laser Coagulation Intravitreal Injections
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[Chances of Artificial Intelligence and Big Data for the Diagnosis and Treatment of Age-related Macular Degeneration].

Klinische Monatsblatter fur Augenheilkunde Oct 31, 2019
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is an effective therapy of the neovascular form of this condition. Multimodal...
Humans Artificial Intelligence Big Data Angiogenesis Inhibitors Vascular Endothelial Growth Factor A Macular Degeneration Intravitreal Injections Ranibizumab Choroidal Neovascularization
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