Proceedings of the National Academy of Sciences of the United States of America
Nov 19, 2024
Natural visual scenes are dominated by spatiotemporal image dynamics, but how the visual system integrates "movie" information over time is unclear. We characterized optic tectal neuronal receptive fields using sparse noise stimuli and reverse correl...
Proceedings of the National Academy of Sciences of the United States of America
Nov 18, 2024
Erectile dysfunction (ED) is a major threat to male fertility and quality of life, and mesenchymal stromal cells (MSCs) are a promising therapeutic option. However, therapeutic outcomes are compromised by low MSC retention and survival rates in corpu...
Proceedings of the National Academy of Sciences of the United States of America
Nov 8, 2024
Cellular deconvolution via bulk RNA sequencing (RNA-seq) presents a cost-effective and efficient alternative to experimental methods such as flow cytometry and single-cell RNA-seq (scRNA-seq) for analyzing the complex cellular composition of tumor mi...
Proceedings of the National Academy of Sciences of the United States of America
Sep 30, 2024
Biomimetic actuation technologies with high muscle strokes, cycle rates, and work capacities are necessary for robotic systems. We present a muscle type that operates based on changes in muscle stiffness caused by volume expansion. This muscle is cre...
Proceedings of the National Academy of Sciences of the United States of America
Sep 13, 2024
is an important cyanobacterium that serves as a versatile and robust model for studying circadian biology and photosynthetic metabolism. Its transcriptional regulatory network (TRN) is of fundamental interest, as it orchestrates the cell's adaptatio...
Proceedings of the National Academy of Sciences of the United States of America
Sep 12, 2024
Animals are born with extensive innate behavioral capabilities, which arise from neural circuits encoded in the genome. However, the information capacity of the genome is orders of magnitude smaller than that needed to specify the connectivity of an ...
Proceedings of the National Academy of Sciences of the United States of America
Sep 6, 2024
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circul...
Proceedings of the National Academy of Sciences of the United States of America
Sep 5, 2024
Anthropogenic habitat destruction and climate change are reshaping the geographic distribution of plants worldwide. However, we are still unable to map species shifts at high spatial, temporal, and taxonomic resolution. Here, we develop a deep learni...
Proceedings of the National Academy of Sciences of the United States of America
Sep 3, 2024
Trajectory inference methods are essential for analyzing the developmental paths of cells in single-cell sequencing datasets. It provides insights into cellular differentiation, transitions, and lineage hierarchies, helping unravel the dynamic proces...