BACKGROUND: Lung adenocarcinoma is one of most threatening disease to human health. Although many efforts have been devoted to its genetic study, few researches have been focused on the transcription factors which regulate tumor initiation and progre...
RATIONALE AND OBJECTIVES: The aim of this study is to develop a deep learning-based multimodal feature interaction-guided fusion (DL-MFIF) framework that integrates macroscopic information from computed tomography (CT) images with microscopic informa...
Journal of cellular and molecular medicine
Aug 1, 2025
The immunoregulatory functions and clinical implications of APOE+ macrophages within the tumour microenvironment of lung adenocarcinoma remain incompletely defined. In this study, single-cell transcriptome analysis revealed distinct subsets of APOE+ ...
UNLABELLED: Lung adenocarcinoma (LUAD) is a heterogeneous disease with substantial genomic differences between individuals of Chinese and European ancestries. Deciphering the timing of driver mutations may lead to insights into tumor evolution that c...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jun 15, 2025
Tumor-associated macrophages (TAMs) are a vital immune component within the tumor microenvironment (TME) of lung adenocarcinoma (LUAD), exerting significant influence on tumor growth, metastasis, and drug resistance. N6-methyladenosine (m6A) modifica...
Lung adenocarcinoma (LUAD) is a morphologically heterogeneous disease, characterized by five primary histological growth patterns. The classification of such patterns is crucial due to their direct relation to prognosis but the high subjectivity and ...
AIM: To assess the predictive performance, risk stratification capabilities, and auxiliary diagnostic utility of radiomics, deep learning, and fusion models in identifying visceral pleural invasion (VPI) in lung adenocarcinoma.
In computational pathology, extracting and representing spatial features from gigapixel whole slide images (WSIs) are fundamental tasks, but due to their large size, WSIs are typically segmented into smaller tiles. A critical aspect of analyzing WSIs...
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