The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis. During ageing, the BBB undergoes structural alterations. Electron microscopy (EM) is the gold standard for studying the structural alterations of the brain vasculatu...
The total number of older persons globally (those aged 60 years and above) was 202 million in 1950; this total multiplied to attain 901 million and is predicted to triple again in 2100. The growth percentage of the elderly population is quickly impro...
Renal stones (RS) are common urologic condition with unclear pathogenesis. Role of aging-related differentially expressed genes (ARDEGs) in RS remains poorly understood. This study aims to identify potential aging-related biomarkers for RS, explore t...
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
OBJECTIVE: Life satisfaction is a key element contributing to successful aging. Limited empirical studies have specifically explored the nature of the relationship between domain-specific satisfaction and global life satisfaction among older adults. ...
BACKGROUND: Identification of accelerated aging and its biomarkers can lead to more timely therapeutic interventions and decision-making. Therefore, we sought to predict aging-related slow gait, a known predictor of accelerated aging, and its determi...
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link to health outcomes like cognition. However, there remains a lack of studies investigating the rate of brain aging and its relationship to cognition. Furthermore...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is currently no cure, and its incidence is on the rise. Early detection is essential for timely intervention and slowing the progression of the disease. While the br...
Age-related hearing loss (ARHL) is one of the most common health conditions among the elderly population. This study used machine learning to screen for a gene signature to predicts ARHL. Four ARHL mice cochlear transcriptome datasets and the mRNA se...
BACKGROUND: Heterotopic ossification is a frequent complication of soft tissue injuries, particularly in tendons. Although ossification in tendon tissue has been reported in a range of aging and disease models, the underlying biomarkers and mechanism...
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