AIMC Topic: Animals

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Significance of NMDA receptor-targeting compounds in neuropsychological disorders: An in-depth review.

European journal of pharmacology
N-methyl-D-aspartate receptors (NMDARs), a subclass of glutamate-gated ion channels, play an integral role in the maintenance of synaptic plasticity and excitation-inhibition balance within the central nervous system (CNS). Any irregularities in NMDA...

Supervised and unsupervised learning reveal heroin-induced impairments in astrocyte structural plasticity.

Science advances
Astrocytes regulate synaptic activity across large brain territories via their complex, interconnected morphology. Emerging evidence supports the involvement of astrocytes in shaping relapse to opioid use through morphological rearrangements in the n...

Swimming in the "Matrix": VR fish pass the Turing test using a simple control law for collective behavior.

Science robotics
Immersive virtual reality reveals that a simple control model from fish schooling can be used to control autonomous vehicles.

Reverse engineering the control law for schooling in zebrafish using virtual reality.

Science robotics
Revealing the evolved mechanisms that give rise to collective behavior is a central objective in the study of cellular and organismal systems. In addition, understanding the algorithmic basis of social interactions in a causal and quantitative way of...

Machine learning and complex network analysis of drug effects on neuronal microelectrode biosensor data.

Scientific reports
Biosensors, such as microelectrode arrays that record in vitro neuronal activity, provide powerful platforms for studying neuroactive substances. This study presents a machine learning workflow to analyze drug-induced changes in neuronal biosensor da...

Integrative Analysis of Lactylation-Associated Features in Abdominal Aortic Aneurysm and Its Immune Microenvironment Utilizing scRNA-seq and Bulk RNA Sequencing.

Circulation journal : official journal of the Japanese Circulation Society
BACKGROUND: Abdominal aortic aneurysm (AAA) is a vascular disease strongly associated with immune dysregulation and metabolic disturbances. Although lactate metabolism and its associated process, lactylation, have been implicated in various diseases,...

Development of non-targeted volatilomics with solid-phase microextraction for the authentication of plant-based milk alternatives.

Talanta
The demand for plant-based milk alternatives (PBMA) has increased substantially, especially among consumers allergic and/or intolerant to animal dairy products and consumers attentive to environmental sustainability. Concurrent with market expansion ...

Digital pathology in veterinary clinical pathology: A review.

Veterinary pathology
Digital pathology has rapidly evolved in the field of veterinary medicine. Although digital histology advancements are widely discussed, clinical pathology specimens are also being digitized for a variety of purposes. These digital images can be used...

The impact of partner interaction on brief social buffering in adolescent female rats as analyzed by deep learning-based object detection algorithms.

Physiology & behavior
Social buffering is a phenomenon whereby the stress response of anyone exposed to a distressing stimulus is alleviated by the presence of conspecific(s). In this study, we aimed to determine whether brief buffering (only 3 min) with conspecific immed...

NeuroXiv: AI-powered open databasing and dynamic mining of brain-wide neuron morphometry.

Nature methods
Neuron morphology has been extensively reconstructed at the whole-brain scale by various projects in recent years. Here, to facilitate interactive exploration in a standardized and scalable manner, we introduce NeuroXiv (neuroxiv.org), a large-scale ...