AIMC Topic: Animals

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Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish.

Annual review of pharmacology and toxicology Dec 17, 2024
In the high-stakes arena of drug discovery, the journey from bench to bedside is hindered by a daunting 92% failure rate, primarily due to unpredicted toxicities and inadequate therapeutic efficacy in clinical trials. The FDA Modernization Act 2.0 he...
Organoids Clinical Trials as Topic Induced Pluripotent Stem Cells Artificial Intelligence Precision Medicine Animals Humans Drug Discovery Genomics Drug Evaluation, Preclinical
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Mind the Step: An Artificial Intelligence-Based Monitoring Platform for Animal Welfare.

Sensors (Basel, Switzerland) Dec 17, 2024
We present an artificial intelligence (AI)-enhanced monitoring framework designed to assist personnel in evaluating and maintaining animal welfare using a modular architecture. This framework integrates multiple deep learning models to automatically ...
Humans Artificial Intelligence Monitoring, Physiologic Animals Swine Animal Welfare Deep Learning Behavior, Animal Cattle
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Habitat Suitability Modelling for the Red Dwarf Honeybee (Apis florea (Linnaeus)) and Its Distribution Prediction Using Machine Learning and Cloud Computing.

Neotropical entomology Dec 17, 2024
Apis florea bees were recently identified in Egypt, marking the second occurrence of this species on the African continent. The objective of this study was to track the distribution of A. florea in Egypt and evaluate its potential for invasive behavi...
Animal Distribution Machine Learning Ecosystem Temperature Egypt Animals Bees
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Low-Cost Approaches in Neuroscience to Teach Machine Learning Using a Cockroach Model.

eNeuro Dec 17, 2024
In an effort to increase access to neuroscience education in underserved communities, we created an educational program that utilizes a simple task to measure place preference of the cockroach () and the open-source free software, SLEAP Estimates Ani...
Nicotine Behavior, Animal Neurosciences Animals Male Cockroaches Machine Learning
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Cytotoxicity, Antiadipogenic, Low-Density Lipoprotein Oxidation Inhibitory Activities, and Acute Toxicity Study of Hydroethanolic Leaf and Bark Extracts.

TheScientificWorldJournal Dec 17, 2024
Obesity is increasingly taking an important stage as a cause of death worldwide, and interventions with a good cost-effectiveness ratio are needed. is one of these natural products with health benefits. Objective. The present study evaluated the cy...
Rats, Wistar Male Rats Plant Leaves Antioxidants Oxidation-Reduction Humans Plant Bark Plant Extracts Adipogenesis Animals Lipoproteins, LDL
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Leveraging machine learning to predict drug permeation: impact of menthol and limonene as enhancers.

Molecular diversity Dec 16, 2024
The present study aimed to develop robust machine learning (ML) models to predict the skin permeability of poorly water-soluble drugs in the presence of menthol and limonene as penetration enhancers (PEs). The ML models were also applied in virtual s...
Humans Machine Learning Limonene Menthol Animals Skin Permeability Skin Absorption
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Strategies for the design of biomimetic cell-penetrating peptides using AI-driven in silico tools for drug delivery.

Biomaterials advances Dec 16, 2024
Cell-penetrating peptides (CPP) have gained rapid attention over the last 25 years; this is attributed to their versatility, customisation, and 'Trojan horse' delivery that evades the immune system. However, the current CPP rational design process is...
Animals Drug Design Biomimetic Materials Cell-Penetrating Peptides Machine Learning Computer Simulation Drug Delivery Systems Humans Artificial Intelligence
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An Artificial Neural Network for Image Classification Inspired by the Aversive Olfactory Learning Neural Circuit in Caenorhabditis elegans.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Dec 16, 2024
This study introduces an artificial neural network (ANN) for image classification task, inspired by the aversive olfactory learning neural circuit in Caenorhabditis elegans (C. elegans). Although artificial neural networks (ANNs) have demonstrated re...
Caenorhabditis elegans Neural Networks, Computer Learning Animals Smell Nerve Net
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Machine Learning-Engineered Nanozyme System for Synergistic Anti-Tumor Ferroptosis/Apoptosis Therapy.

Small (Weinheim an der Bergstrasse, Germany) Dec 16, 2024
Nanozymes with multienzyme-like activity have sparked significant interest in anti-tumor therapy via responding to the tumor microenvironment (TME). However, the consequent induction of protective autophagy substantially compromises the therapeutic e...
Cell Line, Tumor Apoptosis Ferroptosis Autophagy Machine Learning Tumor Microenvironment Animals Humans
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Damage explains function in spiking neural networks representing central pattern generator.

Journal of neural engineering Dec 16, 2024
Complex biological systems have evolved to control movement dynamics despite noisy and unpredictable inputs and processing delays that necessitate forward predictions. The staple example in vertebrates is the locomotor control emerging from interacti...
Animals Models, Neurological Action Potentials Neural Networks, Computer Computer Simulation Nerve Net Central Pattern Generators Cats Locomotion
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