AIMC Topic: Animals

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Breaking the cycle of parasitic diseases with edutainment: The intersection of entertainment and education.

PLoS neglected tropical diseases May 28, 2025
Parasitic diseases represent a substantial public health challenge worldwide. Traditional educational strategies have often fallen short in driving sustained behavioral shifts that are nonetheless essential for reducing the burden of these diseases. ...
Animals Health Education Parasitic Diseases Humans
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Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq.

Frontiers in immunology May 28, 2025
BACKGROUND: Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, the role of mitophagy in the p...
Humans Disease Models, Animal Pancreatitis Mice Computational Biology Gene Expression Profiling Mitophagy Biomarkers Single-Cell Analysis Machine Learning Gene Regulatory Networks Animals RNA-Seq Algorithms Single-Cell Gene Expression Analysis
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Development and application of cell-based bioassay in aquatic toxicity assessment.

Aquatic toxicology (Amsterdam, Netherlands) May 26, 2025
Cell-based bioassays provide a dynamic and physiologically relevant platform for investigating cellular responses to chemical, biological, and environmental stimuli. Unlike traditional biochemical assays, cell-based bioassays utilize living cells to ...
Animals Water Pollutants, Chemical Biological Assay Toxicity Tests
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Mechanistic exploration of hexokinase 2 and metabolism in diabetic cardiomyopathy.

Molecular medicine reports May 26, 2025
The pathogenesis of diabetic cardiomyopathy (DCM) remains incompletely understood. The present study employed weighted gene co‑expression network analysis to analyze the DCM transcriptome dataset from the Gene Expression Omnibus (GEO) database to ide...
Gene Expression Profiling Transcriptome Animals Male Diabetic Cardiomyopathies Hexokinase Mice Disease Models, Animal Humans
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Easy and Fast Discrimination of Female Sand Flies from Species with Infrared Spectroscopy and Multivariate Analysis.

Analytical chemistry May 26, 2025
Accurate identification of sandfly species is critical for controlling and preventing the spread of visceral leishmaniasis, a major public health concern in Latin America. Morphological similarities between female and present a significant challeng...
Psychodidae Animals Machine Learning Principal Component Analysis Support Vector Machine Female Multivariate Analysis Spectroscopy, Fourier Transform Infrared
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Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.

Journal of nanobiotechnology May 26, 2025
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery strategies a...
Drug Delivery Systems Animals Permeability Biological Products Brain Blood-Brain Barrier Humans
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Volumetric atlas of the rat inner ear from microCT and iDISCO+ cleared temporal bones.

PeerJ May 26, 2025
BACKGROUND: Volumetric atlases are an invaluable tool in neuroscience and otolaryngology, greatly aiding experiment planning and surgical interventions, as well as the interpretation of experimental and clinical data. The rat is a major animal model ...
X-Ray Microtomography Atlases as Topic Temporal Bone Rats Ear, Inner Animals
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Prediction of reproductive and developmental toxicity using an attention and gate augmented graph convolutional network.

Scientific reports May 25, 2025
Due to the diverse molecular structures of chemical compounds and their intricate biological pathways of toxicity, predicting their reproductive and developmental toxicity remains a challenge. Traditional Quantitative Structure-Activity Relationship ...
Deep Learning Reproduction Humans Computer Simulation Neural Networks, Computer Animals Quantitative Structure-Activity Relationship
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A novel feature fusion and mountain gazelle optimizer based framework for the recognition of jute pests in sustainable agriculture.

Scientific reports May 25, 2025
Sustainable agriculture is an approach that involves adopting and developing agricultural practices to increase efficiency and preserve resources, both environmentally and economically. Jute is one of the primary sources of income grown in many count...
Crops, Agricultural Algorithms Animals Artificial Intelligence Agriculture
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Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential.

Theranostics May 25, 2025
Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenes...
DNA Repair Neoplasms Humans DNA, Circular Disease Progression Animals
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