AIMC Topic: Animals

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An AI-driven strategy for active compounds discovery and non-destructive quality control in traditional Chinese medicine: A case of Xuefu Zhuyu Oral Liquid.

Talanta
The modernization and globalization of traditional Chinese medicine (TCM) face challenges such as unclear active compounds and inadequate quality control. Taking Xuefu Zhuyu Oral Liquid (XZOL) as an example, this study proposed an artificial intellig...

AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma.

International journal of molecular sciences
The management of nasopharyngeal cancer (NPC) is rapidly evolving, with immune checkpoint inhibitors emerging as a prominent treatment approach. However, drug development targeting specific molecular and cellular abnormalities in NPC has slowed. Rece...

Single-cell RNA sequencing reveals immunological link between house dust mite allergy and childhood asthma.

Scientific reports
Allergic asthma in children is typically associated with house dust mites (HDM) as the key allergen. Nevertheless, the diagnostic rate remains below 60% due to the absence of specific symptoms and diagnostic markers, which hinders the implementation ...

Virtual white matter: a novel system for cross-dish neural interaction and modulation.

Journal of neural engineering
. Biological neural networks (BNNs) are characterized by complex interregional connectivity, allowing for seamless communication between different brain regions.models traditionally consist of single-dish neural cultures that cannot recapitulate the ...

Neural Code Translation With LIF Neuron Microcircuits.

Neural computation
Spiking neural networks (SNNs) provide an energy-efficient alternative to traditional artificial neural networks, leveraging diverse neural encoding schemes such as rate, time-to-first-spike (TTFS), and population-based binary codes. Each encoding me...

Dynamics and Bifurcation Structure of a Mean-Field Model of Adaptive Exponential Integrate-and-Fire Networks.

Neural computation
The study of brain activity spans diverse scales and levels of description and requires the development of computational models alongside experimental investigations to explore integrations across scales. The high dimensionality of spiking networks p...

Dynamics of Continuous Attractor Neural Networks With Spike Frequency Adaptation.

Neural computation
Attractor neural networks consider that neural information is stored as stationary states of a dynamical system formed by a large number of interconnected neurons. The attractor property empowers a neural system to encode information robustly, but it...

A customizable P hydrogel applicator for brachytherapy of skin hemangioma based on machine learning and 3D-printing.

Journal of materials chemistry. B
Skin hemangioma is a tumor originating from skin blood vessels, which often occurs in infants and children. Brachytherapy with the P-based radionuclide applicator is an effective non-invasive therapeutic method. However, the inordinance of lesions is...

Sex differences in bladder cancer: understanding biological and clinical implications.

Biology of sex differences
Bladder cancer (BC) remains a significant global health concern, with substantial sex and racial disparities in incidence, progression, and outcomes. BC is the sixth most common cancer among males and the seventeenth most common among females worldwi...

A novel hybrid fruit fly and simulated annealing optimized faster R-CNN for detection and classification of tomato plant leaf diseases.

Scientific reports
Modern agriculture increasingly relies on technologies that enhance farmers' efficiency and economic growth. One challenge is the accurate identification of disease-affected plants, whose characteristics like structure, size, texture, and color can v...