AIMC Topic: Anti-Retroviral Agents
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Characterization of low level viraemia in HIV-infected patients receiving boosted protease inhibitor-based antiretroviral regimens.
HIV research & clinical practice
Jan 30, 2020
To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequenc...
HIV Protease Inhibitors
gag Gene Products, Human Immunodeficiency Virus
United Kingdom
Drug Resistance, Multiple, Viral
HIV Protease
Male
Viral Load
Humans
Middle Aged
Female
Mutation
HIV Infections
Adult
HIV-1
Viremia
High-Throughput Nucleotide Sequencing
Anti-Retroviral Agents
Antiretroviral Therapy, Highly Active
A comparison of machine learning techniques for classification of HIV patients with antiretroviral therapy-induced mitochondrial toxicity from those without mitochondrial toxicity.
BMC medical research methodology
Nov 27, 2019
BACKGROUND: Antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality. However, therapeutic benefit of ART is often limited by delayed drug-associated toxicity. Nucleoside reverse transcriptase inhibitors (NRTIs) are ...
Multioutput Perturbation-Theory Machine Learning (PTML) Model of ChEMBL Data for Antiretroviral Compounds.
Molecular pharmaceutics
Aug 30, 2019
Retroviral infections, such as HIV, are, until now, diseases with no cure. Medicine and pharmaceutical chemistry need and consider it a huge goal to define target proteins of new antiretroviral compounds. ChEMBL manages Big Data features with a compl...
HIV is associated with endothelial activation despite ART, in a sub-Saharan African setting.
Neurology(R) neuroimmunology & neuroinflammation
Dec 21, 2018
OBJECTIVE: To study the relationship between endothelial dysfunction, HIV infection, and stroke in Malawians.
Validation of the Behavior of a Knowledge Base Implementing Clinical Guidelines for Point-of-Care Antiretroviral Toxicity Monitoring.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
This study investigated the automated detection of antiretroviral toxicities in structured electronic health records data. The evaluation compared responses generated by 5 clinical pharmacists and 1 prototype knowledge-based application for 15 random...
A survey of machine learning applications in HIV clinical research and care.
Computers in biology and medicine
Nov 9, 2017
A wealth of genetic, demographic, clinical and biomarker data is collected from routine clinical care of HIV patients and exists in the form of medical records available among the medical care and research communities. Machine learning (ML) methods h...
IFPTML Multi-Output Model for Anti-Retroviral Compounds Including the Drug Structure and Target Protein Sequence Information.
Journal of chemical information and modeling
May 12, 2025
Retroviruses such as HIV cause significant diseases in humans and other organisms, making the discovery of antiretroviral (ARV) drugs a critical priority. While databases like ChEMBL contain valuable information, their complexity poses challenges. Th...
Machine Learning Analysis Reveals Novel Neuroimaging and Clinical Signatures of Frailty in HIV.
Journal of acquired immune deficiency syndromes (1999)
Aug 1, 2020
BACKGROUND: Frailty is an important clinical concern for the aging population of people living with HIV (PLWH). The objective of this study was to identify the combination of risk features that distinguish frail from nonfrail individuals.
STABILITY INDICATIVE HPLC DETERMINATION OF RELATED SUBSTANCES AND IDENTIFICATION OF POTENTIAL DEGRADANTS USING LC-MS IN TRIPLE COMBINATION ANTIRETROVIRAL TABLETS.
Acta poloniae pharmaceutica
Jan 1, 2017
A rapid stability indicating liquid chromatography method was developed and validated for the simultaneous quantitation of related substances of antiretrovirals in combined oral dosage formulation. Separation was achieved using a Waters, Xterra RP-18...
[Prevalence of potential drug-drug interactions involving antiretroviral drugs in Buenos Aires, Argentina].
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia
Oct 1, 2016
INTRODUCTION: Antiretroviral agents (ARVs) have a high potential for drug interactions. However, the prevalence and risk factors for clinically significant drug-drug interactions (CSDDIs) with ARVs from Latin American countries is unknown.
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