AIMC Topic: Antineoplastic Combined Chemotherapy Protocols
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Synergistic Drug Combination Prediction by Integrating Multiomics Data in Deep Learning Models.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
Intrinsic and acquired drug resistance is a major challenge in cancer therapy. Synergistic drug combinations could help to overcome drug resistance. However, the number of possible drug combinations is enormous, and it is infeasible to experimentally...
[Stage Ⅳ Breast Cancer with Difficulty in Initiating Chemotherapy-A Case Report].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2019
We report a case of breast cancer(T4b[skin], N1, M1[lung], ER-, PR-, HER2 3+)in a 63-year-old woman with liver dysfunction of unknown cause(T-Bil 3.6mg/dL, ALP 3,483 U/L, AST 214 U/L, ALT 320 U/L, g / -GTP 1,943 U/L). Further- more, serum CA19-9(4,67...
[A Case of Two Curative Resections for the Peritoneal Dissemination of Transverse Colon Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2019
No large clinical trials have been conducted to prove the efficacy of peritoneal dissemination resection for colorectal cancer, and no evidence has shown the usefulness of resection for metachronous peritoneal dissemination. An elderly woman in her 7...
[A Case of Breast Cancer Liver Metastases with Jaundice Responding to Chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2019
A 50-year-old woman was referred to our hospital due to breast cancer with multiple liver metastasis diagnosed by CT scan. Laboratory findings showed liver dysfunction(T-Bil 7.6mg/dL)with marked elevation of tumor markers(CEA 727.9 ng/mL). Breast tum...
[A Patient with Multiple Colorectal Liver Metastases for Whom Partial Splenic Embolization Contributed Extremely to Maintain Multidisciplinary Treatment].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2019
After approximately 2.5 years of chemotherapy at the referred hospital, a 69-year-old man with double colon cancer and unresectable liver metastases(H3)sought consultation. A total of 8 liver metastases were deemed resectable; however, the disease wa...
[A Case of Disseminated Carcinomatosis of the Bone Marrow Developing 15 Months after Gastrectomy].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2019
The patient was a 60-year-old man who underwent distal gastrectomy for gastric cancer. The pathological diagnosis was Stage ⅡB. He received adjuvant chemotherapy(capecitabine plus oxaliplatin: CapeOX)for 6months and the postoperative course was uneve...
Validation of a Cyclic Algorithm to Proxy Number of Lines of Systemic Cancer Therapy Using Administrative Data.
JCO clinical cancer informatics
Aug 1, 2019
PURPOSE: Researchers are automating the process for identifying the number of lines of systemic cancer therapy received by patients. To date, algorithm development has involved manual modifications to predefined classification rules. In this study, w...
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers.
Annals of oncology : official journal of the European Society for Medical Oncology
Jun 1, 2019
INTRODUCTION: Immunotherapy is regarded as one of the major breakthroughs in cancer treatment. Despite its success, only a subset of patients responds-urging the quest for predictive biomarkers. We hypothesize that artificial intelligence (AI) algori...
Humans
Artificial Intelligence
Tomography, X-Ray Computed
Melanoma
Survival Rate
Lung Neoplasms
Machine Learning
Algorithms
Prognosis
Follow-Up Studies
Predictive Value of Tests
Programmed Cell Death 1 Receptor
Immunotherapy
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
[A Case of Laparoscopic Resection for Locally Advanced Primary Rectal Cancer after Neoadjuvant Chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2018
We treateda 70-year-oldfemale patient with locally advancedrectal cancer accompaniedby metastases to other organs. Three courses of S-1 plus oxaliplatin(SOX)therapy were administered as neoadjuvant chemotherapy(NAC), andthe cancer was subsequently tr...
[Nephrotoxicity of a Short Hydration Method for the Cisplatin Regimen in Patients with Gastric Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2018
BACKGROUND: S-1 plus cisplatin(CDDP)has been a key regimen for advanced gastric cancer treatment. However, CDDP confers dose-limiting nephrotoxicity, requires a hospital stay for conventional massive hydration, and reduces patients' quality of life. ...
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